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MAPRE2 microtubule associated protein RP/EB family member 2 [ Homo sapiens (human) ]

Gene ID: 10982, updated on 7-Jun-2020

Summary

Official Symbol
MAPRE2provided by HGNC
Official Full Name
microtubule associated protein RP/EB family member 2provided by HGNC
Primary source
HGNC:HGNC:6891
See related
Ensembl:ENSG00000166974 MIM:605789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EB1; EB2; RP1; CSCSC2
Summary
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in brain (RPKM 59.8), heart (RPKM 31.4) and 24 other tissues See more
Orthologs

Genomic context

See MAPRE2 in Genome Data Viewer
Location:
18q12.1-q12.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (34976928..35143470)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (32556892..32723434)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene dystrobrevin alpha Neighboring gene ribosomal protein L10a pseudogene 13 Neighboring gene uncharacterized LOC105372061 Neighboring gene Sharpr-MPRA regulatory region 7107 Neighboring gene zinc finger protein 397 Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene zinc finger protein 271, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ARF protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of focal adhesion disassembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein RP/EB family member 2
Names
APC-binding protein EB1
APC-binding protein EB2
T-cell activation protein, EB1 family
end-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047123.1 RefSeqGene

    Range
    5001..171543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143826.2NP_001137298.1  microtubule-associated protein RP/EB family member 2 isoform 2

    See identical proteins and their annotated locations for NP_001137298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC009277, AC015967, BC007318, BM673789, DC341673
    Consensus CDS
    CCDS45851.1
    UniProtKB/Swiss-Prot
    Q15555
    Related
    ENSP00000396074.1, ENST00000413393.5
    Conserved Domains (3) summary
    pfam00307
    Location:16100
    CH; Calponin homology (CH) domain
    pfam03271
    Location:219256
    EB1; EB1-like C-terminal motif
    cl01709
    Location:74131
    PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold
  2. NM_001143827.3NP_001137299.1  microtubule-associated protein RP/EB family member 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015967, AK294833, BM673789
    Consensus CDS
    CCDS45850.1
    UniProtKB/Swiss-Prot
    Q15555
    Related
    ENSP00000407723.1, ENST00000436190.6
    Conserved Domains (3) summary
    pfam00307
    Location:47131
    CH; Calponin homology (CH) domain
    pfam03271
    Location:250287
    EB1; EB1-like C-terminal motif
    cl01709
    Location:105162
    PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold
  3. NM_001256420.2NP_001243349.1  microtubule-associated protein RP/EB family member 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015967, AK090945, BM673789
    Consensus CDS
    CCDS58619.1
    UniProtKB/Swiss-Prot
    Q15555
    Related
    ENSP00000446343.1, ENST00000538170.6
    Conserved Domains (3) summary
    pfam00307
    Location:3090
    CH; Calponin homology (CH) domain
    pfam03271
    Location:209246
    EB1; EB1-like C-terminal motif
    cl01709
    Location:64121
    PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold
  4. NM_014268.4NP_055083.1  microtubule-associated protein RP/EB family member 2 isoform 1

    See identical proteins and their annotated locations for NP_055083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC015967, BC007318, BM673789, DC354326
    Consensus CDS
    CCDS11910.1
    UniProtKB/Swiss-Prot
    Q15555
    UniProtKB/TrEMBL
    A0A024RC33
    Related
    ENSP00000300249.4, ENST00000300249.10
    Conserved Domains (1) summary
    cl26556
    Location:59313
    EB1; EB1-like C-terminal motif

RNA

  1. NR_046177.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the primary ORF, as found in variant 2. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC015967, AK296251, BM673789

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    34976928..35143470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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