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RAB32 RAB32, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 10981, updated on 23-Nov-2021

Summary

Official Symbol
RAB32provided by HGNC
Official Full Name
RAB32, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9772
See related
Ensembl:ENSG00000118508 MIM:612906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
Expression
Broad expression in bone marrow (RPKM 49.7), spleen (RPKM 19.8) and 23 other tissues See more
Orthologs
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Genomic context

See RAB32 in Genome Data Viewer
Location:
6q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (146543833..146554953)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (146864969..146876089)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 1 Neighboring gene FUN14 domain containing 2 pseudogene 3 Neighboring gene RNA, 5S ribosomal pseudogene 222 Neighboring gene Sharpr-MPRA regulatory region 4102 Neighboring gene ADGB divergent transcript Neighboring gene androglobin Neighboring gene uncharacterized LOC105378041

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
GeneReviews: Not available
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AP-1 adaptor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables AP-3 adaptor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables BLOC-2 complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosome to melanosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in melanosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in melanosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in early endosome lumen IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome membrane TAS
Traceable Author Statement
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondria-associated endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006834.5NP_006825.1  ras-related protein Rab-32

    See identical proteins and their annotated locations for NP_006825.1

    Status: REVIEWED

    Source sequence(s)
    BC015061, BQ018663
    Consensus CDS
    CCDS5210.1
    UniProtKB/Swiss-Prot
    Q13637
    Related
    ENSP00000356465.3, ENST00000367495.4
    Conserved Domains (1) summary
    cd04107
    Location:26224
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    146543833..146554953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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