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UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI [ Homo sapiens (human) ]

Gene ID: 10975, updated on 17-Jun-2024

Summary

Official Symbol
UQCR11provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase, complex III subunit XIprovided by HGNC
Primary source
HGNC:HGNC:30862
See related
Ensembl:ENSG00000127540 MIM:609711; AllianceGenome:HGNC:30862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UQCR; QCR10; 0710008D09Rik
Summary
This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in colon (RPKM 36.3), fat (RPKM 35.6) and 25 other tissues See more
Orthologs
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Genomic context

See UQCR11 in Genome Data Viewer
Location:
19p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1597169..1605462, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1567992..1576285, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1597168..1605461, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 477, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584307-1584918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584919-1585529 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1590888-1591877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13615 Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1606417-1607038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13618 Neighboring gene RNA, U6 small nuclear 1223, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1626353-1626854 Neighboring gene transcription factor 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1649155-1649654 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1651633-1651855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13623 Neighboring gene MPRA-validated peak3223 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1667070-1667570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1668943-1669693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1672373-1672900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690448-1690998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690999-1691550 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1722988-1723177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1725449-1725948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1743285-1743784 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1743951-1744173 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:1747113-1748312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1748390-1748908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757201-1757790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757791-1758378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1762447-1762983 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1765801-1766322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1767617-1768311 Neighboring gene one cut homeobox 3 Neighboring gene uncharacterized LOC101928543

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cytochrome b-c1 complex subunit 10
Names
complex III subunit 10
complex III subunit XI
ubiquinol-cytochrome c reductase complex 6.4 kDa protein
ubiquinol-cytochrome c reductase, 6.4kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006830.4NP_006821.1  cytochrome b-c1 complex subunit 10

    See identical proteins and their annotated locations for NP_006821.1

    Status: REVIEWED

    Source sequence(s)
    AA807820, BC003594, DW465790
    Consensus CDS
    CCDS12073.1
    UniProtKB/Swiss-Prot
    B2R542, D6W5Z4, O14957, Q9UEA3, Q9UPK4
    Related
    ENSP00000467262.1, ENST00000591899.8
    Conserved Domains (1) summary
    pfam08997
    Location:155
    UCR_6-4kD; Ubiquinol-cytochrome C reductase complex, 6.4kD protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1597169..1605462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1567992..1576285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)