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TMED10 transmembrane p24 trafficking protein 10 [ Homo sapiens (human) ]

Gene ID: 10972, updated on 8-Jul-2021

Summary

Official Symbol
TMED10provided by HGNC
Official Full Name
transmembrane p24 trafficking protein 10provided by HGNC
Primary source
HGNC:HGNC:16998
See related
Ensembl:ENSG00000170348 MIM:605406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA)
Summary
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 111.9), endometrium (RPKM 61.7) and 25 other tissues See more
Orthologs
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Genomic context

See TMED10 in Genome Data Viewer
Location:
14q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (75131469..75176612, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75598172..75643315, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene zinc finger C2HC-type containing 1C Neighboring gene NIMA related kinase 9 Neighboring gene HIF1AP pseudogene 1 Neighboring gene RNA, U4atac small nuclear 14, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr14.1538

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TMED10; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed
Rev rev HIV-1 Rev is identified to have a physical interaction with transmembrane emp24-like trafficking protein 10 (TMED10) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Expression of HIV-1 Tat downregulates the abundance of transmembrane emp24-like trafficking protein 10 (TMED10) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle TAS
Traceable Author Statement
more info
PubMed 
involved_in COPI-coated vesicle budding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in COPII vesicle coating TAS
Traceable Author Statement
more info
PubMed 
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytosol to ERGIC protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to ERGIC IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to alkaloid IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle cargo loading TAS
Traceable Author Statement
more info
PubMed 
involved_in vesicle targeting, to, from or within Golgi ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in COPI-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in COPI-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cis-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
part_of gamma-secretase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in trans-Golgi network transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in transport vesicle TAS
Traceable Author Statement
more info
 
located_in zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transmembrane emp24 domain-containing protein 10
Names
21 kDa transmembrane trafficking protein
p24 family protein delta-1
p24delta
p24delta1
testicular tissue protein Li 206
transmembrane emp24-like trafficking protein 10
transmembrane protein Tmp21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006827.6NP_006818.3  transmembrane emp24 domain-containing protein 10 precursor

    See identical proteins and their annotated locations for NP_006818.3

    Status: REVIEWED

    Source sequence(s)
    AK056156, AL832012, BG675810, BX248754, BX504393, CN420777, DB528262, X97442
    Consensus CDS
    CCDS9840.1
    UniProtKB/Swiss-Prot
    P49755
    UniProtKB/TrEMBL
    A0A024R6I3
    Related
    ENSP00000303145.4, ENST00000303575.9
    Conserved Domains (1) summary
    pfam01105
    Location:31213
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    75131469..75176612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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