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RAB40B RAB40B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 10966, updated on 24-Nov-2020

Summary

Official Symbol
RAB40Bprovided by HGNC
Official Full Name
RAB40B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:18284
See related
Ensembl:ENSG00000141542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAR; SEC4L
Summary
The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 11.7), kidney (RPKM 5.9) and 23 other tissues See more
Orthologs

Genomic context

See RAB40B in Genome Data Viewer
Location:
17q25.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82654973..82698702, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80614943..80656598, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene forkhead box K2 Neighboring gene uncharacterized LOC105371942 Neighboring gene WD repeat domain 45B Neighboring gene microRNA 4525 Neighboring gene uncharacterized LOC105376791 Neighboring gene uncharacterized LOC101929552

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-40B
Names
GTP-binding protein homologous to Saccharomyces cerevisiae SEC4
SOCS box-containing protein RAR
protein Rar

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006822.3NP_006813.1  ras-related protein Rab-40B

    See identical proteins and their annotated locations for NP_006813.1

    Status: REVIEWED

    Source sequence(s)
    AC024361
    Consensus CDS
    CCDS11816.1
    UniProtKB/Swiss-Prot
    Q12829
    Related
    ENSP00000461785.1, ENST00000571995.6
    Conserved Domains (2) summary
    cd04121
    Location:9278
    Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c
    cd03742
    Location:187229
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82654973..82698702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256334.4XP_005256391.1  ras-related protein Rab-40B isoform X3

    Conserved Domains (2) summary
    cd03742
    Location:127169
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:9218
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017024042.1XP_016879531.1  ras-related protein Rab-40B isoform X3

    Conserved Domains (2) summary
    cd03742
    Location:127169
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:9218
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_024450551.1XP_024306319.1  ras-related protein Rab-40B isoform X3

    Conserved Domains (2) summary
    cd03742
    Location:127169
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:9218
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_024450550.1XP_024306318.1  ras-related protein Rab-40B isoform X3

    Conserved Domains (2) summary
    cd03742
    Location:127169
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:9218
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_006722271.3XP_006722334.1  ras-related protein Rab-40B isoform X2

    Conserved Domains (2) summary
    cd03742
    Location:147189
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:8238
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011523528.2XP_011521830.1  ras-related protein Rab-40B isoform X1

    Conserved Domains (3) summary
    smart00175
    Location:13160
    RAB; Rab subfamily of small GTPases
    cd03742
    Location:170212
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:30261
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_017024043.1XP_016879532.1  ras-related protein Rab-40B isoform X3

    Conserved Domains (2) summary
    cd03742
    Location:127169
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:9218
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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