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IFI44L interferon induced protein 44 like [ Homo sapiens (human) ]

Gene ID: 10964, updated on 26-Oct-2022

Summary

Official Symbol
IFI44Lprovided by HGNC
Official Full Name
interferon induced protein 44 likeprovided by HGNC
Primary source
HGNC:HGNC:17817
See related
Ensembl:ENSG00000137959 MIM:613975; AllianceGenome:HGNC:17817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GS3686; TLDC5B; C1orf29
Summary
Predicted to enable GTP binding activity. Involved in defense response to virus. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 16.8), bone marrow (RPKM 13.1) and 23 other tissues See more
Orthologs
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Genomic context

See IFI44L in Genome Data Viewer
Location:
1p31.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78620448..78646145)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78459314..78485000)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79086133..79111830)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 23 Neighboring gene prostaglandin F receptor Neighboring gene interferon induced protein 44 Neighboring gene ribosomal protein L23 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common variants associated with general and MMR vaccine-related febrile seizures.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interferon-induced protein 44-like (IFI44L) in human B cells PubMed
env HIV-1 gp120-treated vaginal epithelial cells show upregulation of interferon-induced protein 44-like (IFI44L) expression as compared to untreated control PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI44L in human monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr upregulates the gene expression of IFI44L in human monocyte-derived macrophages PubMed
Vpu vpu The expression of IFI44L mRNA increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates IFI44L protein expression PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interferon-induced protein 44-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375646.1NP_001362575.1  interferon-induced protein 44-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC104837
    Consensus CDS
    CCDS687.2
    UniProtKB/Swiss-Prot
    Q99984
    Conserved Domains (1) summary
    cd00882
    Location:201286
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
  2. NM_001375647.1NP_001362576.1  interferon-induced protein 44-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104837
    Consensus CDS
    CCDS90985.1
    UniProtKB/TrEMBL
    B4E019
    Related
    ENSP00000504938.1, ENST00000679998.1
  3. NM_001375648.1NP_001362577.1  interferon-induced protein 44-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104837, AK223087, AK303187
    Consensus CDS
    CCDS90985.1
    UniProtKB/TrEMBL
    B4E019
    Related
    ENSP00000506722.1, ENST00000680295.1
  4. NM_001375649.1NP_001362578.1  interferon-induced protein 44-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104837
    Consensus CDS
    CCDS90985.1
    UniProtKB/TrEMBL
    B4E019
    Related
    ENSP00000506384.1, ENST00000681613.1
  5. NM_001375650.1NP_001362579.1  interferon-induced protein 44-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104837
    Consensus CDS
    CCDS90985.1
    UniProtKB/TrEMBL
    B4E019
    Related
    ENSP00000506096.1, ENST00000459784.6
  6. NM_006820.4NP_006811.2  interferon-induced protein 44-like isoform 1

    See identical proteins and their annotated locations for NP_006811.2

    Status: VALIDATED

    Source sequence(s)
    AC104837, AK225442, AW015958, DC390321
    Consensus CDS
    CCDS687.2
    UniProtKB/Swiss-Prot
    Q53G44, Q99984
    Related
    ENSP00000359787.4, ENST00000370751.10
    Conserved Domains (1) summary
    cd00882
    Location:201286
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    78620448..78646145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710304.5XP_006710367.1  interferon-induced protein 44-like isoform X1

    See identical proteins and their annotated locations for XP_006710367.1

    UniProtKB/TrEMBL
    B4E019

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    78459314..78485000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)