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STIP1 stress induced phosphoprotein 1 [ Homo sapiens (human) ]

Gene ID: 10963, updated on 6-Jan-2019

Summary

Official Symbol
STIP1provided by HGNC
Official Full Name
stress induced phosphoprotein 1provided by HGNC
Primary source
HGNC:HGNC:11387
See related
Ensembl:ENSG00000168439 MIM:605063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521
Summary
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Expression
Ubiquitous expression in testis (RPKM 66.9), adrenal (RPKM 34.3) and 25 other tissues See more
Orthologs

Genomic context

See STIP1 in Genome Data Viewer
Location:
11q13.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (64185272..64204548)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63952206..63972020)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene uncharacterized LOC105369339 Neighboring gene fermitin family member 3 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of stress-induced-phosphoprotein 1 (STIP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, stress-induced-phosphoprotein 1 (STIP1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of stress-induced-phosphoprotein 1 (STIP1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Prion diseases, organism-specific biosystem (from KEGG)
    Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Prion diseases, conserved biosystem (from KEGG)
    Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA binding HDA PubMed 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to interleukin-7 IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
stress-induced-phosphoprotein 1
Names
Hsp70/Hsp90-organizing protein
NY-REN-11 antigen
epididymis secretory sperm binding protein Li 94n
hsc70/Hsp90-organizing protein
renal carcinoma antigen NY-REN-11
transformation-sensitive protein IEF SSP 3521

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282652.1NP_001269581.1  stress-induced-phosphoprotein 1 isoform a

    See identical proteins and their annotated locations for NP_001269581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC039299, BM679538, DA123899, DA781468
    Consensus CDS
    CCDS60827.1
    UniProtKB/Swiss-Prot
    P31948
    Related
    ENSP00000351646.5, ENST00000358794.9
    Conserved Domains (2) summary
    sd00006
    Location:411435
    TPR; TPR repeat [structural motif]
    cl26005
    Location:54579
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_001282653.1NP_001269582.1  stress-induced-phosphoprotein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, uses an alternate start codon, and contains an in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK297319, BC039299, BM679538, DA781468
    Consensus CDS
    CCDS60828.1
    UniProtKB/Swiss-Prot
    P31948
    Related
    ENSP00000445957.1, ENST00000538945.5
    Conserved Domains (6) summary
    smart00727
    Location:468507
    STI1; Heat shock chaperonin-binding motif
    smart00028
    Location:276304
    TPR; Tetratricopeptide repeats
    sd00006
    Location:340364
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:370403
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:336401
    TPR_11; TPR repeat
    pfam13424
    Location:231304
    TPR_12; Tetratricopeptide repeat
  3. NM_006819.2NP_006810.1  stress-induced-phosphoprotein 1 isoform b

    See identical proteins and their annotated locations for NP_006810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    BM679538, DA781468, M86752
    Consensus CDS
    CCDS8058.1
    UniProtKB/Swiss-Prot
    P31948
    UniProtKB/TrEMBL
    V9HW72
    Related
    ENSP00000305958.4, ENST00000305218.8
    Conserved Domains (2) summary
    sd00006
    Location:364388
    TPR; TPR repeat [structural motif]
    cl26005
    Location:7532
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    64185272..64204548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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