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STIP1 stress induced phosphoprotein 1 [ Homo sapiens (human) ]

Gene ID: 10963, updated on 27-Nov-2024

Summary

Official Symbol
STIP1provided by HGNC
Official Full Name
stress induced phosphoprotein 1provided by HGNC
Primary source
HGNC:HGNC:11387
See related
Ensembl:ENSG00000168439 MIM:605063; AllianceGenome:HGNC:11387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521
Summary
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Expression
Ubiquitous expression in testis (RPKM 66.9), adrenal (RPKM 34.3) and 25 other tissues See more
Orthologs
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Genomic context

See STIP1 in Genome Data Viewer
Location:
11q13.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64185272..64204543)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64175217..64194489)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63952744..63972015)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63803443-63804345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63804346-63805247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63815687-63816245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63816558-63817058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63820013-63820556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63820557-63821100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63821645-63822187 Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63826482-63827200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63836633-63837360 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:63840775-63840963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63860723-63861393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63861723-63862230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63877842-63878622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63889359-63890290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63896949-63897542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63913439-63913940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63919856-63920851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63920852-63921846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63933104-63933604 Neighboring gene uncharacterized LOC105369339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3460 Neighboring gene MPRA-validated peak1294 silencer Neighboring gene uncharacterized LOC124902686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63948751-63949252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63949253-63949752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63951637-63952142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3462 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:63972802-63973364 and GRCh37_chr11:63973365-63973927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63992564-63993286 Neighboring gene FERM domain containing kindlin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene uncharacterized LOC124902687 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of stress-induced-phosphoprotein 1 (STIP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, stress-induced-phosphoprotein 1 (STIP1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of stress-induced-phosphoprotein 1 (STIP1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to interleukin-7 IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of protein folding chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
stress-induced-phosphoprotein 1
Names
Hsp70/Hsp90-organizing protein
NY-REN-11 antigen
epididymis secretory sperm binding protein Li 94n
hsc70/Hsp90-organizing protein
renal carcinoma antigen NY-REN-11
transformation-sensitive protein IEF SSP 3521

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282652.2NP_001269581.1  stress-induced-phosphoprotein 1 isoform a

    See identical proteins and their annotated locations for NP_001269581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC039299, DA123899, DA781468
    Consensus CDS
    CCDS60827.1
    UniProtKB/TrEMBL
    A8K690
    Related
    ENSP00000351646.5, ENST00000358794.9
    Conserved Domains (2) summary
    sd00006
    Location:411435
    TPR; TPR repeat [structural motif]
    cl26005
    Location:54579
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_001282653.2NP_001269582.1  stress-induced-phosphoprotein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, uses an alternate start codon, and contains an in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK297319, BC039299, DA781468
    Consensus CDS
    CCDS60828.1
    UniProtKB/TrEMBL
    A8K690
    Related
    ENSP00000445957.1, ENST00000538945.5
    Conserved Domains (6) summary
    smart00727
    Location:468507
    STI1; Heat shock chaperonin-binding motif
    smart00028
    Location:276304
    TPR; Tetratricopeptide repeats
    sd00006
    Location:340364
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:370403
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:336401
    TPR_11; TPR repeat
    pfam13424
    Location:231304
    TPR_12; Tetratricopeptide repeat
  3. NM_006819.3NP_006810.1  stress-induced-phosphoprotein 1 isoform b

    See identical proteins and their annotated locations for NP_006810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    DA781468, M86752
    Consensus CDS
    CCDS8058.1
    UniProtKB/Swiss-Prot
    B4DM70, F5H0T1, G3XAD8, P31948, Q3ZCU9, Q5TZU9
    UniProtKB/TrEMBL
    A8K690, V9HW72
    Related
    ENSP00000305958.5, ENST00000305218.9
    Conserved Domains (2) summary
    TIGR00990
    Location:7532
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:364388
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64185272..64204543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64175217..64194489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)