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Cald1 caldesmon 1 [ Mus musculus (house mouse) ]

Gene ID: 109624, updated on 8-May-2024

Summary

Official Symbol
Cald1provided by MGI
Official Full Name
caldesmon 1provided by MGI
Primary source
MGI:MGI:88250
See related
Ensembl:ENSMUSG00000029761 AllianceGenome:MGI:88250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
caldesmon; 4833423D12Rik; C920027I18Rik
Summary
Predicted to enable actin binding activity and myosin binding activity. Predicted to be involved in actin filament bundle assembly and angiogenesis. Predicted to act upstream of or within regulation of smooth muscle contraction. Located in actin cap and membrane. Is expressed in early conceptus; intestine smooth muscle circular layer; oocyte; and retina. Orthologous to human CALD1 (caldesmon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 210.7), placenta adult (RPKM 27.0) and 5 other tissues See more
Orthologs
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Genomic context

See Cald1 in Genome Data Viewer
Location:
6 B1; 6 15.07 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34575433..34752404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34598495..34775469)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52898 Neighboring gene STARR-seq mESC enhancer starr_15540 Neighboring gene predicted gene, 32942 Neighboring gene STARR-seq mESC enhancer starr_15541 Neighboring gene predicted gene 13861 Neighboring gene STARR-seq mESC enhancer starr_15542 Neighboring gene predicted gene, 38787 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ATP/GTP binding protein-like 3 Neighboring gene predicted gene, 46957

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC30319

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding TAS
Traceable Author Statement
more info
PubMed 
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of smooth muscle contraction TAS
Traceable Author Statement
more info
PubMed 
NOT involved_in response to transforming growth factor beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cap IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347100.1NP_001334029.1  caldesmon isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102668, AC153627
    Consensus CDS
    CCDS85029.1
    UniProtKB/TrEMBL
    E9Q0M9, E9QA16
    Related
    ENSMUSP00000110678.2, ENSMUST00000115026.8
    Conserved Domains (1) summary
    pfam02029
    Location:53523
    Caldesmon
  2. NM_145575.3NP_663550.1  caldesmon isoform 2

    See identical proteins and their annotated locations for NP_663550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC153627, AK160593, BQ769983, BY308240, CX568419
    Consensus CDS
    CCDS39456.1
    UniProtKB/TrEMBL
    D3Z6I7, Q8VCQ8
    Related
    ENSMUSP00000110673.2, ENSMUST00000115021.8
    Conserved Domains (1) summary
    pfam02029
    Location:255517
    Caldesmon; Caldesmon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34575433..34752404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505348.5XP_006505411.1  caldesmon isoform X7

    See identical proteins and their annotated locations for XP_006505411.1

    UniProtKB/TrEMBL
    E9QA15
    Related
    ENSMUSP00000110679.2, ENSMUST00000115027.8
    Conserved Domains (1) summary
    pfam02029
    Location:363759
    Caldesmon
  2. XM_006505352.4XP_006505415.1  caldesmon isoform X5

    UniProtKB/TrEMBL
    E9Q0M9
    Conserved Domains (1) summary
    pfam02029
    Location:53523
    Caldesmon
  3. XM_036165745.1XP_036021638.1  caldesmon isoform X5

    UniProtKB/TrEMBL
    E9Q0M9
    Conserved Domains (1) summary
    pfam02029
    Location:53523
    Caldesmon
  4. XM_030255093.1XP_030110953.1  caldesmon isoform X6

    UniProtKB/TrEMBL
    E9Q0M9, E9QA16
    Conserved Domains (1) summary
    pfam02029
    Location:53523
    Caldesmon
  5. XM_006505345.5XP_006505408.3  caldesmon isoform X1

    UniProtKB/TrEMBL
    E9QA15
    Conserved Domains (1) summary
    pfam02029
    Location:434830
    Caldesmon
  6. XM_006505346.4XP_006505409.3  caldesmon isoform X2

    UniProtKB/TrEMBL
    E9QA15
    Conserved Domains (1) summary
    pfam02029
    Location:434830
    Caldesmon
  7. XM_030255090.2XP_030110950.2  caldesmon isoform X3

    UniProtKB/TrEMBL
    E9QA15
    Conserved Domains (1) summary
    pfam02029
    Location:434802
    Caldesmon
  8. XM_006505351.4XP_006505414.3  caldesmon isoform X4

    UniProtKB/TrEMBL
    D3Z6I7
    Conserved Domains (1) summary
    pfam02029
    Location:124594
    Caldesmon

RNA

  1. XR_004942901.1 RNA Sequence

  2. XR_004942902.1 RNA Sequence

  3. XR_004942906.1 RNA Sequence

  4. XR_004942907.1 RNA Sequence

  5. XR_004942903.1 RNA Sequence

  6. XR_004942899.1 RNA Sequence

  7. XR_004942898.1 RNA Sequence

  8. XR_004942900.1 RNA Sequence

  9. XR_004942904.1 RNA Sequence

  10. XR_004942905.1 RNA Sequence