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LMAN2 lectin, mannose binding 2 [ Homo sapiens (human) ]

Gene ID: 10960, updated on 19-Jun-2024

Summary

Official Symbol
LMAN2provided by HGNC
Official Full Name
lectin, mannose binding 2provided by HGNC
Primary source
HGNC:HGNC:16986
See related
Ensembl:ENSG00000169223 MIM:609551; AllianceGenome:HGNC:16986
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP36B; VIP36; C5orf8
Summary
This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in thyroid (RPKM 56.0), testis (RPKM 45.6) and 25 other tissues See more
Orthologs
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Genomic context

See LMAN2 in Genome Data Viewer
Location:
5q35.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177331567..177351668, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177874790..177894892, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176758568..176778669, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:176728411-176729610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16677 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176730775-176731652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176737000-176737866 Neighboring gene PRELI domain containing 1 Neighboring gene RAB24, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23705 Neighboring gene MAX dimerization protein 3 Neighboring gene Sharpr-MPRA regulatory region 13731 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176746939-176747440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176747441-176747940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176751079-176751579 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:176753137-176754080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176763024-176763649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176765883-176766836 Neighboring gene ribosomal protein S20 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23706 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176778754-176778968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176784977-176785477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176793955-176794594 Neighboring gene regulator of G protein signaling 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176794595-176795233 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176796333-176797184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176800703-176801203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176814616-176815116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176815117-176815617 Neighboring gene VISTA enhancer hs2229 Neighboring gene solute carrier family 34 member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176823005-176823660 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176824881-176825056

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
EBI GWAS Catalog
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lectin, mannose-binding 2 (LMAN2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with LMAN2; predicted interaction to be within the endoplasmic reticulum PubMed
env HIV-1 gp160 is identified to have a physical interaction with lectin, mannose-binding 2 (LMAN2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with lectin, mannose-binding 2 (LMAN2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MXD3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables D-mannose binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
vesicular integral-membrane protein VIP36
Names
epididymis secretory sperm binding protein
glycoprotein GP36b
vesicular integral protein of 36 kDa
vesicular integral-membrane protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006816.3NP_006807.1  vesicular integral-membrane protein VIP36 precursor

    See identical proteins and their annotated locations for NP_006807.1

    Status: REVIEWED

    Source sequence(s)
    AK222609, BC017263, DC404202
    Consensus CDS
    CCDS4417.1
    UniProtKB/Swiss-Prot
    Q12907, Q53HH1
    UniProtKB/TrEMBL
    A0A384NPY7, A8K7T4
    Related
    ENSP00000303366.7, ENST00000303127.12
    Conserved Domains (1) summary
    cd06901
    Location:53301
    lectin_VIP36_VIPL; VIP36 and VIPL type 1 transmembrane proteins, lectin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    177331567..177351668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177874790..177894892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)