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TMED2 transmembrane p24 trafficking protein 2 [ Homo sapiens (human) ]

Gene ID: 10959, updated on 5-Jul-2020

Summary

Official Symbol
TMED2provided by HGNC
Official Full Name
transmembrane p24 trafficking protein 2provided by HGNC
Primary source
HGNC:HGNC:16996
See related
Ensembl:ENSG00000086598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p24; P24A; RNP24; p24b1; p24beta1
Expression
Ubiquitous expression in thyroid (RPKM 170.2), colon (RPKM 110.3) and 25 other tissues See more
Orthologs

Genomic context

See TMED2 in Genome Data Viewer
Location:
12q24.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (123584552..123598582)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124069076..124082688)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microRNA 3908 Neighboring gene TMED2 divergent transcript Neighboring gene DEAD-box helicase 55 Neighboring gene uncharacterized LOC105370041 Neighboring gene small nucleolar RNA, H/ACA box 9B Neighboring gene eukaryotic translation initiation factor 2B subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane emp24 domain trafficking protein 2 (TMED2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21323

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPI coating of Golgi vesicle TAS
Traceable Author Statement
more info
PubMed 
COPII vesicle coating TAS
Traceable Author Statement
more info
PubMed 
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cargo loading into vesicle TAS
Traceable Author Statement
more info
PubMed 
heart looping IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
somite rostral/caudal axis specification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COPI-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 
zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transmembrane emp24 domain-containing protein 2
Names
coated vesicle membrane protein
membrane protein p24A
p24 family protein beta-1
transmembrane emp24 domain trafficking protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321445.2NP_001308374.1  transmembrane emp24 domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC055713, AI954929, BC025957, BI086507, BP226125, CA445272, DA559763
    UniProtKB/Swiss-Prot
    Q15363
    Conserved Domains (1) summary
    pfam01105
    Location:20203
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  2. NM_006815.4NP_006806.1  transmembrane emp24 domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006806.1

    Status: VALIDATED

    Source sequence(s)
    AC055713, BC025957, BI086507
    Consensus CDS
    CCDS9250.1
    UniProtKB/Swiss-Prot
    Q15363
    UniProtKB/TrEMBL
    Q6FHT8
    Related
    ENSP00000262225.3, ENST00000262225.8
    Conserved Domains (1) summary
    pfam01105
    Location:20196
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    123584552..123598582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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