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BTG3 BTG anti-proliferation factor 3 [ Homo sapiens (human) ]

Gene ID: 10950, updated on 1-Jun-2020

Summary

Official Symbol
BTG3provided by HGNC
Official Full Name
BTG anti-proliferation factor 3provided by HGNC
Primary source
HGNC:HGNC:1132
See related
Ensembl:ENSG00000154640 MIM:605674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANA; TOB5; TOFA; APRO4; TOB55; ANA/BTG3
Summary
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in testis (RPKM 24.4), placenta (RPKM 23.0) and 25 other tissues See more
Orthologs

Genomic context

See BTG3 in Genome Data Viewer
Location:
21q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (17593653..17612940, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (18965968..18985268, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 163, pseudogene Neighboring gene basic transcription factor 3 like 4 pseudogene 1 Neighboring gene CXADR Ig-like cell adhesion molecule Neighboring gene BTG3 antisense RNA 1 Neighboring gene uncharacterized LOC105372741 Neighboring gene C21orf91 overlapping transcript 1 Neighboring gene chromosome 21 open reading frame 91

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein BTG3
Names
B-cell translocation gene 3
BTG family member 3
abundant in neuroepithelium area protein
protein Tob5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130914.2NP_001124386.1  protein BTG3 isoform a

    See identical proteins and their annotated locations for NP_001124386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK289408, BC011957, BF110486, DA381239
    Consensus CDS
    CCDS46636.1
    UniProtKB/Swiss-Prot
    Q14201
    UniProtKB/TrEMBL
    Q6IAU3
    Related
    ENSP00000344609.6, ENST00000339775.10
    Conserved Domains (1) summary
    cl15439
    Location:1104
    BTG; BTG family
  2. NM_006806.5NP_006797.3  protein BTG3 isoform b

    See identical proteins and their annotated locations for NP_006797.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK289408, BF110486, DA381239, DR155504
    Consensus CDS
    CCDS13569.1
    UniProtKB/Swiss-Prot
    Q14201
    UniProtKB/TrEMBL
    Q6IAU3
    Related
    ENSP00000284879.7, ENST00000348354.6
    Conserved Domains (1) summary
    smart00099
    Location:1108
    btg1; tob/btg1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    17593653..17612940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529441.1XP_011527743.1  protein BTG3 isoform X1

    Conserved Domains (1) summary
    cl15439
    Location:11114
    BTG; BTG family
  2. XM_017028266.1XP_016883755.1  protein BTG3 isoform X3

    UniProtKB/Swiss-Prot
    Q14201
    UniProtKB/TrEMBL
    Q6IAU3
    Conserved Domains (1) summary
    smart00099
    Location:1108
    btg1; tob/btg1 family
  3. XM_017028265.1XP_016883754.1  protein BTG3 isoform X3

    UniProtKB/Swiss-Prot
    Q14201
    UniProtKB/TrEMBL
    Q6IAU3
    Conserved Domains (1) summary
    smart00099
    Location:1108
    btg1; tob/btg1 family
  4. XM_024452051.1XP_024307819.1  protein BTG3 isoform X1

    Conserved Domains (1) summary
    cl15439
    Location:11114
    BTG; BTG family
  5. XM_024452052.1XP_024307820.1  protein BTG3 isoform X2

    Conserved Domains (1) summary
    cl15439
    Location:1104
    BTG; BTG family

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187627.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    448..9207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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