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PRSS21 serine protease 21 [ Homo sapiens (human) ]

Gene ID: 10942, updated on 11-Jun-2021

Summary

Official Symbol
PRSS21provided by HGNC
Official Full Name
serine protease 21provided by HGNC
Primary source
HGNC:HGNC:9485
See related
Ensembl:ENSG00000007038 MIM:608159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESP1; ESP-1; TEST1; TESTISIN
Summary
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Biased expression in testis (RPKM 26.0), bone marrow (RPKM 4.4) and 4 other tissues See more
Orthologs
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Genomic context

See PRSS21 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2817237..2821719)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2867238..2871720)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 3C Neighboring gene serine protease 41 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 4 Neighboring gene zymogen granule protein 16B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PRSS21 PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag Depletion of the PRSS21 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
testisin
Names
eosinophil serine protease 1
protease, serine 21
serine protease from eosinophils

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270452.2NP_001257381.1  testisin isoform 4 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA860356, AB031331, BI827608, BX454526
    UniProtKB/Swiss-Prot
    Q9Y6M0
    Related
    ENSP00000458341.1, ENST00000574813.5
    Conserved Domains (2) summary
    smart00020
    Location:41194
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42184
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_006799.4NP_006790.1  testisin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006790.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB031331, AF058300
    Consensus CDS
    CCDS10478.1
    UniProtKB/Swiss-Prot
    Q9Y6M0
    Related
    ENSP00000005995.3, ENST00000005995.8
    Conserved Domains (1) summary
    cd00190
    Location:42283
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_144956.3NP_659205.1  testisin isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_659205.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA860356, AB031331, BI334059, BX454526
    UniProtKB/Swiss-Prot
    Q9Y6M0
    Related
    ENSP00000460351.1, ENST00000574265.1
    Conserved Domains (2) summary
    smart00020
    Location:41279
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42281
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. NM_144957.3NP_659206.1  testisin isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_659206.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA860356, AB031331, BX454526, CB529999
    Consensus CDS
    CCDS45388.1
    UniProtKB/Swiss-Prot
    Q9Y6M0
    Related
    ENSP00000407741.3, ENST00000450020.7
    Conserved Domains (2) summary
    smart00020
    Location:41267
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42269
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_073012.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA860356, AB031331, BG717268, BX454526

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2817237..2821719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022875.1XP_016878364.1  testisin isoform X1

  2. XM_017022878.1XP_016878367.1  testisin isoform X4

  3. XM_017022876.1XP_016878365.1  testisin isoform X2

  4. XM_017022877.1XP_016878366.1  testisin isoform X3

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171812.1 Reference GRCh38.p13 PATCHES

    Range
    419..1184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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