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GPR75 G protein-coupled receptor 75 [ Homo sapiens (human) ]

Gene ID: 10936, updated on 22-Sep-2022

Summary

Official Symbol
GPR75provided by HGNC
Official Full Name
G protein-coupled receptor 75provided by HGNC
Primary source
HGNC:HGNC:4526
See related
Ensembl:ENSG00000119737 MIM:606704; AllianceGenome:HGNC:4526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRchr2; WI31133
Summary
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]
Expression
Broad expression in brain (RPKM 7.2), thyroid (RPKM 1.2) and 16 other tissues See more
Orthologs
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Genomic context

See GPR75 in Genome Data Viewer
Location:
2p16.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (53852912..53859967, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (53849132..53856193, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (54080049..54087104, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GPR75-ASB3 readthrough Neighboring gene small nucleolar RNA U13 Neighboring gene microRNA 3682 Neighboring gene proteasome activator subunit 4 Neighboring gene Sharpr-MPRA regulatory region 11857 Neighboring gene acylphosphatase 2 Neighboring gene ribosomal protein L21 pseudogene 30

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

General gene information

Markers

Readthrough GPR75-ASB3

Readthrough gene: GPR75-ASB3, Included gene: ASB3

Homology

Clone Names

  • MGC132002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006794.4NP_006785.1  probable G-protein coupled receptor 75

    See identical proteins and their annotated locations for NP_006785.1

    Status: VALIDATED

    Source sequence(s)
    AC008068, AF072693, AK314885
    Consensus CDS
    CCDS1849.1
    UniProtKB/Swiss-Prot
    O95800, Q6NWR2
    Related
    ENSP00000378195.2, ENST00000394705.3
    Conserved Domains (1) summary
    pfam00001
    Location:59237
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    53852912..53859967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    53849132..53856193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)