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GPR75 G protein-coupled receptor 75 [ Homo sapiens (human) ]

Gene ID: 10936, updated on 7-Oct-2019

Summary

Official Symbol
GPR75provided by HGNC
Official Full Name
G protein-coupled receptor 75provided by HGNC
Primary source
HGNC:HGNC:4526
See related
Ensembl:ENSG00000119737 MIM:606704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRchr2; WI31133
Summary
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]
Expression
Broad expression in brain (RPKM 7.2), thyroid (RPKM 1.2) and 16 other tissues See more
Orthologs

Genomic context

See GPR75 in Genome Data Viewer
Location:
2p16.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (53852912..53859967, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (54080050..54087170, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GPR75-ASB3 readthrough Neighboring gene uncharacterized LOC112268415 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene microRNA 3682 Neighboring gene proteasome activator subunit 4 Neighboring gene acylphosphatase 2 Neighboring gene ribosomal protein L21 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

General gene information

Markers

Readthrough GPR75-ASB3

Readthrough gene: GPR75-ASB3, Included gene: ASB3

Homology

Clone Names

  • MGC132002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 75

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006794.4NP_006785.1  probable G-protein coupled receptor 75

    See identical proteins and their annotated locations for NP_006785.1

    Status: VALIDATED

    Source sequence(s)
    AC008068, AF072693, AK314885
    Consensus CDS
    CCDS1849.1
    UniProtKB/Swiss-Prot
    O95800
    Related
    ENSP00000378195.2, ENST00000394705.3
    Conserved Domains (1) summary
    pfam00001
    Location:59237
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    53852912..53859967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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