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Abraxas2 BRISC complex subunit [ Mus musculus (house mouse) ]

Gene ID: 109359, updated on 21-Apr-2024

Summary

Official Symbol
Abraxas2provided by MGI
Official Full Name
BRISC complex subunitprovided by MGI
Primary source
MGI:MGI:1926116
See related
Ensembl:ENSMUSG00000030965 AllianceGenome:MGI:1926116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abro1; Fam175b; C430003P19Rik
Summary
Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of apoptotic process; protein K63-linked deubiquitination; and response to ischemia. Acts upstream of or within cellular response to freezing. Located in cytoplasm and nucleus. Orthologous to human ABRAXAS2 (abraxas 2, BRISC complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 10.5), CNS E11.5 (RPKM 9.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 F3; 7 76.32 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (132460954..132486843)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132859225..132885114)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8216 Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene STARR-positive B cell enhancer mm9_chr7:139848293-139848593 Neighboring gene STARR-seq mESC enhancer starr_20301 Neighboring gene STARR-seq mESC enhancer starr_20302 Neighboring gene family with sequence similarity 53, member B Neighboring gene EEF1A lysine methyltransferase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:140044265-140044448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:140050715-140050898 Neighboring gene RIKEN cDNA 1500002F19 gene Neighboring gene STARR-seq mESC enhancer starr_20305 Neighboring gene predicted gene, 46003 Neighboring gene predicted gene 45502

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to freezing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BRISC complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule minus-end ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
BRISC complex subunit Abraxas 2
Names
BRISC complex subunit Abro1
abraxas brother protein 1
family with sequence similarity 175, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198017.3NP_932134.3  BRISC complex subunit Abraxas 2

    Status: VALIDATED

    Source sequence(s)
    AC099627, AK171524, AV375824
    Consensus CDS
    CCDS21928.3
    UniProtKB/Swiss-Prot
    Q3TB08, Q3TCJ1, Q8K0R4
    UniProtKB/TrEMBL
    Z4YJY0
    Related
    ENSMUSP00000081541.7, ENSMUST00000084497.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    132460954..132486843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)