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APOBEC2 apolipoprotein B mRNA editing enzyme catalytic subunit 2 [ Homo sapiens (human) ]

Gene ID: 10930, updated on 8-Dec-2018

Summary

Official Symbol
APOBEC2provided by HGNC
Official Full Name
apolipoprotein B mRNA editing enzyme catalytic subunit 2provided by HGNC
Primary source
HGNC:HGNC:605
See related
Ensembl:ENSG00000124701 MIM:604797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP1; ARCD1
Expression
Biased expression in heart (RPKM 45.3), prostate (RPKM 9.9) and 1 other tissue See more
Orthologs

Genomic context

See APOBEC2 in Genome Data Viewer
Location:
6p21.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (41053201..41064891)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41020940..41032630)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene unc-5 family C-terminal like Neighboring gene translocator protein 2 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene adenylate cyclase 10, soluble pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Formation of the Editosome, organism-specific biosystem (from REACTOME)
    Formation of the Editosome, organism-specific biosystemThe editosome for C to U editing in mammals consist of a member of cytidine deaminase family of enzymes, apoB mRNA editig catalytic polypeptide 1 (APOBEC-1) and a complementing specificity factor (AC...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • mRNA Editing, organism-specific biosystem (from REACTOME)
    mRNA Editing, organism-specific biosystemAfter transcription, some RNA molecules are altered to contain bases not encoded in the genome. Most often this involves the editing or modification of one base to another, but in some organisms can ...
  • mRNA Editing: C to U Conversion, organism-specific biosystem (from REACTOME)
    mRNA Editing: C to U Conversion, organism-specific biosystemThe best characterized case of C to U editing is in the intestinal apolipoprotein B transcript, where the editing event creates a premature translation stop codon and consequently leads to a shorter ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytidine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA demethylation IDA
Inferred from Direct Assay
more info
PubMed 
cytidine deamination IEA
Inferred from Electronic Annotation
more info
 
cytidine to uridine editing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytidine to uridine editing IDA
Inferred from Direct Assay
more info
PubMed 
mRNA modification IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C->U-editing enzyme APOBEC-2
Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
mRNA(cytosine(6666)) deaminase 2
probable C->U-editing enzyme APOBEC-2
NP_006780.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006789.3NP_006780.1  C->U-editing enzyme APOBEC-2

    See identical proteins and their annotated locations for NP_006780.1

    Status: VALIDATED

    Source sequence(s)
    AF086496, AK313288, BC047767
    Consensus CDS
    CCDS4848.1
    UniProtKB/Swiss-Prot
    Q9Y235
    Related
    ENSP00000244669.2, ENST00000244669.2
    Conserved Domains (3) summary
    pfam05240
    Location:160208
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:52221
    APOBEC_N; APOBEC-like N-terminal domain
    cl00269
    Location:61151
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    41053201..41064891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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