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Tmem250 transmembrane protein 250 [ Mus musculus (house mouse) ]

Gene ID: 109299, updated on 7-Apr-2025

Summary

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Official Symbol
Tmem250provided by MGI
Official Full Name
transmembrane protein 250provided by MGI
Primary source
MGI:MGI:1924939
See related
Ensembl:ENSMUSG00000087679 AllianceGenome:MGI:1924939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem250-ps; C330006A16Rik
Summary
Predicted to be involved in positive regulation of cell population proliferation and positive regulation of viral process. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to human TMEM250 (transmembrane protein 250). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in adrenal adult (RPKM 143.7), ovary adult (RPKM 80.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem250 in Genome Data Viewer
Location:
2 A3; 2 18.35 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26026819..26030518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26136807..26140506, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03972 Neighboring gene nucleus accumbens associated 2, BEN and BTB (POZ) domain containing Neighboring gene STARR-seq mESC enhancer starr_03973 Neighboring gene VISTA enhancer mm561 Neighboring gene predicted gene, 54107 Neighboring gene STARR-seq mESC enhancer starr_03976 Neighboring gene predicted gene, 35745 Neighboring gene LIM homeobox protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 250
Names
transmembrane protein 250, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256521.1 → NP_001243450.1  transmembrane protein 250

    See identical proteins and their annotated locations for NP_001243450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL845455, DN176963
    Consensus CDS
    CCDS89452.1
    UniProtKB/TrEMBL
    A0A571BES4
    Related
    ENSMUSP00000158596.2, ENSMUST00000133808.2
    Conserved Domains (1) summary
    pfam17685
    Location:1 → 139
    DUF5533; Family of unknown function (DUF5533)

  2. NM_001256522.1 → NP_001243451.1  transmembrane protein 250

    See identical proteins and their annotated locations for NP_001243451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL845455
    Consensus CDS
    CCDS89452.1
    UniProtKB/TrEMBL
    A0A571BES4
    Related
    ENSMUSP00000158791.2, ENSMUST00000163836.2
    Conserved Domains (1) summary
    pfam17685
    Location:1 → 139
    DUF5533; Family of unknown function (DUF5533)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26026819..26030518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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