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Rlf rearranged L-myc fusion sequence [ Mus musculus (house mouse) ]

Gene ID: 109263, updated on 11-Apr-2024

Summary

Official Symbol
Rlfprovided by MGI
Official Full Name
rearranged L-myc fusion sequenceprovided by MGI
Primary source
MGI:MGI:1924705
See related
Ensembl:ENSMUSG00000049878 AllianceGenome:MGI:1924705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MommeD8; 9230110M18Rik
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within histone H3-K4 monomethylation and regulation of DNA methylation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; liver; male reproductive system; spleen; and urinary system. Orthologous to human RLF (RLF zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E18 (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

Location:
4 D2.2; 4 56.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (121003080..121072318, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (121145883..121215121, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit gamma, pseudogene 3 Neighboring gene predicted gene 12882 Neighboring gene STARR-positive B cell enhancer ABC_E8954 Neighboring gene STARR-seq mESC enhancer starr_11261 Neighboring gene predicted gene, 30102 Neighboring gene predicted gene, 40239 Neighboring gene STARR-seq mESC enhancer starr_11263 Neighboring gene STARR-seq mESC enhancer starr_11264 Neighboring gene predicted gene 12888

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346660.1NP_001333589.1  zinc finger protein Rlf

    Status: VALIDATED

    Source sequence(s)
    AL606927
    Consensus CDS
    CCDS84789.1
    UniProtKB/TrEMBL
    A2A7F4, E9Q532
    Related
    ENSMUSP00000050825.6, ENSMUST00000056635.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    121003080..121072318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319915.2XP_017175404.1  zinc finger protein Rlf isoform X1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006502657.4XP_006502720.1  zinc finger protein Rlf isoform X1

    See identical proteins and their annotated locations for XP_006502720.1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_006502658.2XP_006502721.1  zinc finger protein Rlf isoform X1

    See identical proteins and their annotated locations for XP_006502721.1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_036163579.1XP_036019472.1  zinc finger protein Rlf isoform X1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_030253080.2XP_030108940.1  zinc finger protein Rlf isoform X1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081013.1: Suppressed sequence

    Description
    NM_001081013.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.