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DBF4 DBF4-CDC7 kinase regulatory subunit [ Homo sapiens (human) ]

Gene ID: 10926, updated on 20-May-2024

Summary

Official Symbol
DBF4provided by HGNC
Official Full Name
DBF4-CDC7 kinase regulatory subunitprovided by HGNC
Primary source
HGNC:HGNC:17364
See related
Ensembl:ENSG00000006634 MIM:604281; AllianceGenome:HGNC:17364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASK; CHIF; DBF4A; ZDBF1
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 30.3), bone marrow (RPKM 10.3) and 9 other tissues See more
Orthologs
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Genomic context

Location:
7q21.12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87876493..87909553)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (89126406..89159470)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87505808..87538868)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 1 Neighboring gene Sharpr-MPRA regulatory region 13989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18351 Neighboring gene RUN domain containing 3B Neighboring gene ReSE screen-validated silencer GRCh37_chr7:87363145-87363320 Neighboring gene NANOG hESC enhancer GRCh37_chr7:87368534-87369080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:87376668-87377257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:87377258-87377846 Neighboring gene NANOG hESC enhancer GRCh37_chr7:87448246-87448747 Neighboring gene solute carrier family 25 member 40 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87505271-87505780 Neighboring gene origin of replication in promoter of DBF4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26234 Neighboring gene uncharacterized LOC124901690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87556085-87556653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87563985-87564562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87564563-87565140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87584727-87585228 Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87663457-87663957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26240 Neighboring gene uncharacterized LOC105375386 Neighboring gene MPRA-validated peak6626 silencer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of Dbf4-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein DBF4 homolog A
Names
DBF4 homolog
DBF4 zinc finger A
DBF4-type zinc finger-containing protein 1
activator of S phase kinase
chiffon homolog A
regulatory subunit of DDK
zinc finger, DBF-type containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318060.2NP_001304989.1  protein DBF4 homolog A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB028069, AC005164, AK302010, BC014909, BC036045
    UniProtKB/Swiss-Prot
    Q9UBU7
    UniProtKB/TrEMBL
    B4DXK0
    Conserved Domains (1) summary
    pfam07535
    Location:61101
    zf-DBF; DBF zinc finger
  2. NM_001318061.2NP_001304990.1  protein DBF4 homolog A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB028069, AC005164, BC035632, BC036045
    UniProtKB/TrEMBL
    B7Z8C6
    Conserved Domains (1) summary
    cl02684
    Location:70112
    zf-DBF; DBF zinc finger
  3. NM_001318062.2NP_001304991.1  protein DBF4 homolog A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB028070, AC005164, BC036045
    UniProtKB/Swiss-Prot
    Q9UBU7
    Conserved Domains (1) summary
    pfam07535
    Location:3474
    zf-DBF; DBF zinc finger
  4. NM_006716.4NP_006707.1  protein DBF4 homolog A isoform 1

    See identical proteins and their annotated locations for NP_006707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB028069, AC005164, BC036045
    Consensus CDS
    CCDS5611.1
    UniProtKB/Swiss-Prot
    A4D1D8, A8K954, O75226, Q75MS6, Q75N01, Q9UBU7, Q9Y2M6
    Related
    ENSP00000265728.1, ENST00000265728.6
    Conserved Domains (1) summary
    cl02684
    Location:294336
    zf-DBF; DBF zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    87876493..87909553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    89126406..89159470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)