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DBF4 DBF4 zinc finger [ Homo sapiens (human) ]

Gene ID: 10926, updated on 21-Dec-2019

Summary

Official Symbol
DBF4provided by HGNC
Official Full Name
DBF4 zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:17364
See related
Ensembl:ENSG00000006634 MIM:604281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASK; CHIF; DBF4A; ZDBF1
Expression
Biased expression in testis (RPKM 30.3), bone marrow (RPKM 10.3) and 9 other tissues See more
Orthologs

Genomic context

See DBF4 in Genome Data Viewer
Location:
7q21.12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (87876493..87909553)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87505544..87538856)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 1 Neighboring gene RUN domain containing 3B Neighboring gene solute carrier family 25 member 40 Neighboring gene origin of replication in promoter of DBF4 Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene uncharacterized LOC105375386 Neighboring gene uncharacterized LOC102723885 Neighboring gene sorcin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
positive regulation of nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Dbf4-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein DBF4 homolog A
Names
DBF4 homolog
DBF4 zinc finger A
DBF4-type zinc finger-containing protein 1
activator of S phase kinase
chiffon homolog A
zinc finger, DBF-type containing 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318060.2NP_001304989.1  protein DBF4 homolog A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB028069, AC005164, AK302010, BC014909, BC036045
    UniProtKB/Swiss-Prot
    Q9UBU7
    UniProtKB/TrEMBL
    B4DXK0
    Conserved Domains (1) summary
    pfam07535
    Location:61101
    zf-DBF; DBF zinc finger
  2. NM_001318061.2NP_001304990.1  protein DBF4 homolog A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB028069, AC005164, BC035632, BC036045
    UniProtKB/Swiss-Prot
    Q9UBU7
    UniProtKB/TrEMBL
    B7Z8C6
    Conserved Domains (1) summary
    cl02684
    Location:70112
    zf-DBF; DBF zinc finger
  3. NM_001318062.2NP_001304991.1  protein DBF4 homolog A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB028070, AC005164, BC036045
    UniProtKB/Swiss-Prot
    Q9UBU7
    Conserved Domains (1) summary
    pfam07535
    Location:3474
    zf-DBF; DBF zinc finger
  4. NM_006716.4NP_006707.1  protein DBF4 homolog A isoform 1

    See identical proteins and their annotated locations for NP_006707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB028069, AC005164, BC036045
    Consensus CDS
    CCDS5611.1
    UniProtKB/Swiss-Prot
    Q9UBU7
    Related
    ENSP00000265728.1, ENST00000265728.6
    Conserved Domains (1) summary
    cl02684
    Location:294336
    zf-DBF; DBF zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    87876493..87909553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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