Format

Send to:

Choose Destination

FASTK Fas activated serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 10922, updated on 18-Nov-2020

Summary

Official Symbol
FASTKprovided by HGNC
Official Full Name
Fas activated serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:24676
See related
Ensembl:ENSG00000164896 MIM:606965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAST
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 16.4), prostate (RPKM 16.0) and 25 other tissues See more
Orthologs

Genomic context

See FASTK in Genome Data Viewer
Location:
7q36.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (151076621..151080861, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150773708..150777970, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 5 Neighboring gene solute carrier family 4 member 2 Neighboring gene transmembrane and ubiquitin like domain containing 1 Neighboring gene uncharacterized LOC107986862 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Fas-activated serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial mRNA stability IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fas-activated serine/threonine kinase
Names
FAST kinase
NP_001245390.1
NP_006703.1
NP_148936.2
XP_005249989.1
XP_005249990.1
XP_011514063.1
XP_011514064.1
XP_011514065.1
XP_016867193.1
XP_016867194.1
XP_024302410.1
XP_024302411.1
XP_024302412.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258461.2NP_001245390.1  fas-activated serine/threonine kinase isoform 5

    See identical proteins and their annotated locations for NP_001245390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
    Source sequence(s)
    AB209783, AC010973, DA253544
    Consensus CDS
    CCDS59088.1
    UniProtKB/Swiss-Prot
    Q14296
    Related
    ENSP00000418516.1, ENST00000482571.2
    Conserved Domains (3) summary
    smart00952
    Location:457509
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:251316
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:331416
    FAST_2; FAST kinase-like protein, subdomain 2
  2. NM_006712.5NP_006703.1  fas-activated serine/threonine kinase isoform 1

    See identical proteins and their annotated locations for NP_006703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC011770, BU682096, DA253544
    Consensus CDS
    CCDS5918.1
    UniProtKB/Swiss-Prot
    Q14296
    UniProtKB/TrEMBL
    A0A090N8Z7
    Related
    ENSP00000297532.6, ENST00000297532.11
    Conserved Domains (3) summary
    smart00952
    Location:484536
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:278343
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:358443
    FAST_2; FAST kinase-like protein, subdomain 2
  3. NM_033015.4NP_148936.2  fas-activated serine/threonine kinase isoform 4

    See identical proteins and their annotated locations for NP_148936.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC010973, BC039026
    Consensus CDS
    CCDS5919.1
    UniProtKB/Swiss-Prot
    Q14296
    UniProtKB/TrEMBL
    A0A090N8I0
    Related
    ENSP00000324817.6, ENST00000353841.6
    Conserved Domains (3) summary
    smart00952
    Location:343395
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:137202
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:217302
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    151076621..151080861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515762.3XP_011514064.1  fas-activated serine/threonine kinase isoform X4

    Conserved Domains (2) summary
    pfam06743
    Location:278343
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:358428
    FAST_2; FAST kinase-like protein, subdomain 2
  2. XM_011515763.1XP_011514065.1  fas-activated serine/threonine kinase isoform X6

    See identical proteins and their annotated locations for XP_011514065.1

    Conserved Domains (3) summary
    smart00952
    Location:316368
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:110175
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:190275
    FAST_2; FAST kinase-like protein, subdomain 2
  3. XM_017011704.1XP_016867193.1  fas-activated serine/threonine kinase isoform X3

    Conserved Domains (3) summary
    smart00952
    Location:423475
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:217282
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:297382
    FAST_2; FAST kinase-like protein, subdomain 2
  4. XM_024446643.1XP_024302411.1  fas-activated serine/threonine kinase isoform X5

    Conserved Domains (2) summary
    pfam06743
    Location:244309
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:324394
    FAST_2; FAST kinase-like protein, subdomain 2
  5. XM_005249932.1XP_005249989.1  fas-activated serine/threonine kinase isoform X1

    See identical proteins and their annotated locations for XP_005249989.1

    UniProtKB/Swiss-Prot
    Q14296
    Conserved Domains (3) summary
    smart00952
    Location:450502
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:244309
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:324409
    FAST_2; FAST kinase-like protein, subdomain 2
  6. XM_024446642.1XP_024302410.1  fas-activated serine/threonine kinase isoform X3

    Conserved Domains (3) summary
    smart00952
    Location:423475
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:217282
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:297382
    FAST_2; FAST kinase-like protein, subdomain 2
  7. XM_024446644.1XP_024302412.1  fas-activated serine/threonine kinase isoform X5

    Conserved Domains (2) summary
    pfam06743
    Location:244309
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:324394
    FAST_2; FAST kinase-like protein, subdomain 2
  8. XM_005249933.4XP_005249990.1  fas-activated serine/threonine kinase isoform X1

    See identical proteins and their annotated locations for XP_005249990.1

    UniProtKB/Swiss-Prot
    Q14296
    Conserved Domains (3) summary
    smart00952
    Location:450502
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:244309
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:324409
    FAST_2; FAST kinase-like protein, subdomain 2
  9. XM_017011705.2XP_016867194.1  fas-activated serine/threonine kinase isoform X7

  10. XM_011515761.3XP_011514063.1  fas-activated serine/threonine kinase isoform X2

    See identical proteins and their annotated locations for XP_011514063.1

    Related
    ENSP00000444498.2, ENST00000540185.5
    Conserved Domains (2) summary
    pfam06743
    Location:278343
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:358443
    FAST_2; FAST kinase-like protein, subdomain 2
Support Center