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COPS8 COP9 signalosome subunit 8 [ Homo sapiens (human) ]

Gene ID: 10920, updated on 21-Dec-2019

Summary

Official Symbol
COPS8provided by HGNC
Official Full Name
COP9 signalosome subunit 8provided by HGNC
Primary source
HGNC:HGNC:24335
See related
Ensembl:ENSG00000198612 MIM:616011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COP9; CSN8; SGN8
Summary
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 28.1), testis (RPKM 22.3) and 25 other tissues See more
Orthologs

Genomic context

See COPS8 in Genome Data Viewer
Location:
2q37.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (237085441..237100474)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (237993870..238007489)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373950 Neighboring gene uncharacterized LOC93463 Neighboring gene uncharacterized LOC105373952 Neighboring gene uncharacterized LOC105373953

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 8 (COPS8; CSN8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1297, MGC43256

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
 
activation of NF-kappaB-inducing kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein deneddylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
COP9 signalosome complex subunit 8
Names
COP9 constitutive photomorphogenic homolog subunit 8
COP9 homolog
JAB1-containing signalosome subunit 8
hCOP9
signalosome subunit 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006710.5NP_006701.1  COP9 signalosome complex subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_006701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC105760, AL038738, BC003090, BC036499
    Consensus CDS
    CCDS2517.1
    UniProtKB/Swiss-Prot
    Q99627
    UniProtKB/TrEMBL
    A0A024R4D1
    Related
    ENSP00000346340.2, ENST00000354371.7
    Conserved Domains (1) summary
    pfam10075
    Location:31166
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
  2. NM_198189.2NP_937832.1  COP9 signalosome complex subunit 8 isoform 2

    See identical proteins and their annotated locations for NP_937832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon compared to variant 1, resulting in translation initiation from a downstream start codon and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL038738, BC003090, BC036499, BF979628
    Consensus CDS
    CCDS42835.1
    UniProtKB/Swiss-Prot
    Q99627
    Related
    ENSP00000375865.2, ENST00000392008.6
    Conserved Domains (1) summary
    pfam10075
    Location:1117
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    237085441..237100474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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