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SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [ Homo sapiens (human) ]

Gene ID: 10910, updated on 1-Jun-2020

Summary

Official Symbol
SUGT1provided by HGNC
Official Full Name
SGT1 homolog, MIS12 kinetochore complex assembly cochaperoneprovided by HGNC
Primary source
HGNC:HGNC:16987
See related
Ensembl:ENSG00000165416 MIM:604098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGT1
Summary
This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in brain (RPKM 4.1), testis (RPKM 3.2) and 25 other tissues See more
Orthologs

Genomic context

See SUGT1 in Genome Data Viewer
Location:
13q14.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (52652703..52700909)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53226830..53262433)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 345 Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2 Neighboring gene chondromodulin Neighboring gene microRNA 759

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
positive regulation by host of symbiont catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein stability IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
kinetochore TAS
Traceable Author Statement
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein SGT1 homolog
Names
SGT1, suppressor of G2 allele of SKP1
putative 40-6-3 protein
suppressor of G2 allele of SKP1, S. cerevisiae, homolog of

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029521.2 RefSeqGene

    Range
    4996..40659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130912.3NP_001124384.1  protein SGT1 homolog isoform B

    See identical proteins and their annotated locations for NP_001124384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as B or SGT1.2) encodes the longest isoform (B).
    Source sequence(s)
    AL139089
    Consensus CDS
    CCDS45050.1
    UniProtKB/Swiss-Prot
    Q9Y2Z0
    UniProtKB/TrEMBL
    A8K7W3
    Related
    ENSP00000367208.4, ENST00000343788.10
    Conserved Domains (2) summary
    sd00006
    Location:4474
    TPR; TPR repeat [structural motif]
    cl26005
    Location:21365
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_001320831.2NP_001307760.1  protein SGT1 homolog isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B.
    Source sequence(s)
    AL139089
    UniProtKB/Swiss-Prot
    Q9Y2Z0
    UniProtKB/TrEMBL
    A8K7W3, B4DYC6
    Conserved Domains (2) summary
    sd00006
    Location:2252
    TPR; TPR repeat [structural motif]
    cl26005
    Location:8277
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  3. NM_006704.5NP_006695.1  protein SGT1 homolog isoform A

    See identical proteins and their annotated locations for NP_006695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as A) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (A) is shorter than isoform B.
    Source sequence(s)
    AL139089
    Consensus CDS
    CCDS9436.1
    UniProtKB/Swiss-Prot
    Q9Y2Z0
    UniProtKB/TrEMBL
    A8K7W3
    Related
    ENSP00000308067.7, ENST00000310528.8
    Conserved Domains (2) summary
    sd00006
    Location:4474
    TPR; TPR repeat [structural motif]
    cl26005
    Location:21333
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    52652703..52700909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020365.1XP_016875854.1  protein SGT1 homolog isoform X1

  2. XM_011534891.2XP_011533193.1  protein SGT1 homolog isoform X3

    See identical proteins and their annotated locations for XP_011533193.1

    Conserved Domains (2) summary
    cd06489
    Location:94177
    p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...
    pfam05002
    Location:204284
    SGS; SGS domain
  3. XM_011534893.3XP_011533195.1  protein SGT1 homolog isoform X5

    Conserved Domains (2) summary
    cd06489
    Location:62145
    p23_CS_hSgt1_like; p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the ...
    pfam05002
    Location:172252
    SGS; SGS domain
  4. XM_017020366.2XP_016875855.1  protein SGT1 homolog isoform X2

  5. XM_017020368.1XP_016875857.1  protein SGT1 homolog isoform X4

  6. XM_017020367.1XP_016875856.1  protein SGT1 homolog isoform X2

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