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Pfdn4 prefoldin 4 [ Mus musculus (house mouse) ]

Gene ID: 109054, updated on 26-Sep-2022

Summary

Official Symbol
Pfdn4provided by MGI
Official Full Name
prefoldin 4provided by MGI
Primary source
MGI:MGI:1923512
See related
Ensembl:ENSMUSG00000052033 AllianceGenome:MGI:1923512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C1; C-1; Pfd4; 0610025M10Rik; 1810063B06Rik
Summary
Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to be located in mitochondrion and nucleus. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN4 (prefoldin subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 16.3), CNS E18 (RPKM 14.7) and 14 other tissues See more
Orthologs
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Genomic context

See Pfdn4 in Genome Data Viewer
Location:
2 H3; 2 91.91 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (170338348..170360990)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170496428..170519070)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34608 Neighboring gene predicted gene, 40000 Neighboring gene cytochrome P450, family 24, subfamily a, polypeptide 1 Neighboring gene predicted gene, 16796 Neighboring gene predicted gene, 40001 Neighboring gene RIKEN cDNA 4930470P17 gene Neighboring gene predicted gene 14637

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of prefoldin complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013369.3NP_001013387.1  prefoldin subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_001013387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 2. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL935134, AL954701
    Consensus CDS
    CCDS50808.1
    UniProtKB/TrEMBL
    Q6P0X1
    Related
    ENSMUSP00000074596.2, ENSMUST00000075087.8
    Conserved Domains (1) summary
    pfam01920
    Location:167
    Prefoldin_2; Prefoldin subunit
  2. NM_001110152.3NP_001103622.1  prefoldin subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_001103622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL954701
    Consensus CDS
    CCDS50807.1
    UniProtKB/TrEMBL
    A0A8C6MQ55, Q3UWL8
    Related
    ENSMUSP00000070596.6, ENSMUST00000063682.12
    Conserved Domains (1) summary
    pfam01920
    Location:23125
    Prefoldin_2; Prefoldin subunit
  3. NM_001199902.2NP_001186831.1  prefoldin subunit 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AL954701
    Consensus CDS
    CCDS57190.1
    UniProtKB/TrEMBL
    E9Q6U4, Q3UWL8
    Related
    ENSMUSP00000130383.2, ENSMUST00000136839.2
    Conserved Domains (1) summary
    pfam01920
    Location:20120
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    170338348..170360990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)