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MAN1A2 mannosidase alpha class 1A member 2 [ Homo sapiens (human) ]

Gene ID: 10905, updated on 5-Aug-2018

Summary

Official Symbol
MAN1A2provided by HGNC
Official Full Name
mannosidase alpha class 1A member 2provided by HGNC
Primary source
HGNC:HGNC:6822
See related
Ensembl:ENSG00000198162 MIM:604345; Vega:OTTHUMG00000012149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAN1B
Summary
Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 10.5), placenta (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See MAN1A2 in Genome Data Viewer
Location:
1p12
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (117367393..117528872)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117910085..118068320)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene V-set domain containing T cell activation inhibitor 1 Neighboring gene long intergenic non-protein coding RNA 1525 Neighboring gene VPS25 pseudogene 1 Neighboring gene uncharacterized LOC100996263

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Golgi apparatus mannose trimming TAS
Traceable Author Statement
more info
 
N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-glycan processing TAS
Traceable Author Statement
more info
PubMed 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
Names
alpha-1,2-mannosidase IB
alpha1,2-mannosidase
processing alpha-1,2-mannosidase IB
NP_006690.1
XP_006710365.1
XP_011538838.1
XP_016855604.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006699.4NP_006690.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

    See identical proteins and their annotated locations for NP_006690.1

    Status: VALIDATED

    Source sequence(s)
    AL157902, AL358072, BC063300, CA449591
    Consensus CDS
    CCDS895.1
    UniProtKB/Swiss-Prot
    O60476
    Related
    ENSP00000348959.3, OTTHUMP00000013983, ENST00000356554.7
    Conserved Domains (2) summary
    pfam01532
    Location:187626
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl21478
    Location:116194
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    117367393..117528872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540536.3XP_011538838.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X2

    Conserved Domains (2) summary
    pfam01532
    Location:187597
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl21478
    Location:116194
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. XM_017000115.1XP_016855604.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X3

  3. XM_006710302.3XP_006710365.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1

    See identical proteins and their annotated locations for XP_006710365.1

    Conserved Domains (2) summary
    pfam01532
    Location:187626
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl21478
    Location:116194
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. XR_001736939.1 RNA Sequence

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