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Nabp1 nucleic acid binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 109019, updated on 27-Feb-2024

Summary

Official Symbol
Nabp1provided by MGI
Official Full Name
nucleic acid binding protein 1provided by MGI
Primary source
MGI:MGI:1923258
See related
Ensembl:ENSMUSG00000026107 AllianceGenome:MGI:1923258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nbp1; Ssb2; Obfc2a; 4930434H03Rik; 4930442A21Rik; 4930488J04Rik; 4933440J18Rik; 5830411E10Rik
Summary
Enables RNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Located in chromosome, telomeric region and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 17.6), placenta adult (RPKM 13.4) and 15 other tissues See more
Orthologs
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Genomic context

See Nabp1 in Genome Data Viewer
Location:
1 C1.1; 1 26.58 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (51504127..51517634, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (51464968..51478475, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330175M20 gene Neighboring gene caveolae associated 2 Neighboring gene THO complex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00877 Neighboring gene STARR-seq mESC enhancer starr_00878 Neighboring gene STARR-positive B cell enhancer mm9_chr1:51515795-51516095 Neighboring gene STARR-positive B cell enhancer ABC_E7721 Neighboring gene STARR-positive B cell enhancer ABC_E1542 Neighboring gene STARR-seq mESC enhancer starr_00879 Neighboring gene STARR-seq mESC enhancer starr_00881 Neighboring gene predicted gene, 17767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:51641775-51642017 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:51650842-51651025 Neighboring gene STARR-positive B cell enhancer mm9_chr1:51653904-51654205 Neighboring gene STARR-seq mESC enhancer starr_00883 Neighboring gene predicted gene, 31636

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2/M transition checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SOSS complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SOSS complex subunit B2
Names
SOSS-B2
oligonucleotide/oligosaccharide-binding fold containing 2A
oligonucleotide/oligosaccharide-binding fold-containing protein 2A
sensor of single-strand DNA complex subunit B2
sensor of ssDNA subunit B2
single-stranded DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310548.1NP_001297477.1  SOSS complex subunit B2 isoform b

    See identical proteins and their annotated locations for NP_001297477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation from a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC125518, AK167652, AY880264, BB609822, BY089463
    Consensus CDS
    CCDS78580.1
    UniProtKB/Swiss-Prot
    Q8BGW5
    Related
    ENSMUSP00000140557.2, ENSMUST00000185534.2
    Conserved Domains (1) summary
    PLN02216
    Location:3671
    PLN02216; protein SRG1
  2. NM_001310549.1NP_001297478.1  SOSS complex subunit B2 isoform b

    See identical proteins and their annotated locations for NP_001297478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation from a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK167652, AY880264, BB609822
    Consensus CDS
    CCDS78580.1
    UniProtKB/Swiss-Prot
    Q8BGW5
    Related
    ENSMUSP00000140469.2, ENSMUST00000188204.7
    Conserved Domains (1) summary
    PLN02216
    Location:3671
    PLN02216; protein SRG1
  3. NM_028696.3NP_082972.2  SOSS complex subunit B2 isoform a

    See identical proteins and their annotated locations for NP_082972.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AY880264
    Consensus CDS
    CCDS35559.1
    UniProtKB/Swiss-Prot
    Q8BGW5, Q8C154, Q8C164
    UniProtKB/TrEMBL
    Q8R2P2
    Related
    ENSMUSP00000027279.6, ENSMUST00000027279.12
    Conserved Domains (1) summary
    cd04491
    Location:2299
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    51504127..51517634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003956258.1 RNA Sequence

  2. XR_001785093.3 RNA Sequence

  3. XR_001785084.3 RNA Sequence

  4. XR_001785088.3 RNA Sequence

  5. XR_004934047.1 RNA Sequence