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E2f8 E2F transcription factor 8 [ Mus musculus (house mouse) ]

Gene ID: 108961, updated on 18-Sep-2024

Summary

Official Symbol
E2f8provided by MGI
Official Full Name
E2F transcription factor 8provided by MGI
Primary source
MGI:MGI:1922038
See related
Ensembl:ENSMUSG00000046179 AllianceGenome:MGI:1922038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4432406C08Rik
Summary
Enables DNA binding activity; DNA-binding transcription repressor activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and trophoblast giant cell differentiation. Acts upstream of or within cell population proliferation. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human E2F8 (E2F transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 17.2), liver E14 (RPKM 16.7) and 16 other tissues See more
Orthologs
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Genomic context

See E2f8 in Genome Data Viewer
Location:
7 B4; 7 31.11 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (48516177..48531821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (48866429..48882073, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1734 Neighboring gene STARR-seq mESC enhancer starr_18887 Neighboring gene zinc finger, DHHC domain containing 13 Neighboring gene STARR-positive B cell enhancer ABC_E3719 Neighboring gene STARR-positive B cell enhancer ABC_E8174 Neighboring gene cysteine and glycine-rich protein 3 Neighboring gene STARR-seq mESC enhancer starr_18888 Neighboring gene STARR-seq mESC enhancer starr_18889 Neighboring gene STARR-seq mESC enhancer starr_18890 Neighboring gene predicted gene 2788 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene neuron navigator 2 Neighboring gene predicted gene, 32849

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell cycle comprising mitosis without cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chorionic trophoblast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor E2F8
Names
E2f family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013368.5NP_001013386.2  transcription factor E2F8

    See identical proteins and their annotated locations for NP_001013386.2

    Status: VALIDATED

    Source sequence(s)
    AK084513, AK160240, BX528987
    Consensus CDS
    CCDS39967.1
    UniProtKB/Swiss-Prot
    Q3U4W2, Q497V7, Q58FA4, Q5PRE4, Q8BQJ5, Q8C3Y5
    Related
    ENSMUSP00000056778.9, ENSMUST00000058745.15
    Conserved Domains (2) summary
    PHA03247
    Location:497830
    PHA03247; large tegument protein UL36; Provisional
    pfam02319
    Location:114182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  2. NM_001360812.1NP_001347741.1  transcription factor E2F8

    Status: VALIDATED

    Source sequence(s)
    AC124977, BC086675, BX528987
    Consensus CDS
    CCDS39967.1
    UniProtKB/Swiss-Prot
    Q3U4W2, Q497V7, Q58FA4, Q5PRE4, Q8BQJ5, Q8C3Y5
    Related
    ENSMUSP00000112883.2, ENSMUST00000119223.2
    Conserved Domains (2) summary
    PHA03247
    Location:497830
    PHA03247; large tegument protein UL36; Provisional
    pfam02319
    Location:114182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    48516177..48531821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540554.3XP_006540617.1  transcription factor E2F8 isoform X1

    See identical proteins and their annotated locations for XP_006540617.1

    UniProtKB/Swiss-Prot
    Q3U4W2, Q497V7, Q58FA4, Q5PRE4, Q8BQJ5, Q8C3Y5
    Conserved Domains (2) summary
    PHA03247
    Location:497830
    PHA03247; large tegument protein UL36; Provisional
    pfam02319
    Location:114182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain