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Irak2 interleukin-1 receptor-associated kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 108960, updated on 14-May-2024

Summary

Official Symbol
Irak2provided by MGI
Official Full Name
interleukin-1 receptor-associated kinase 2provided by MGI
Primary source
MGI:MGI:2429603
See related
Ensembl:ENSMUSG00000060477 AllianceGenome:MGI:2429603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRAK-2; 6330415L08Rik
Summary
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; negative regulation of DNA-binding transcription factor activity; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including Peyer's patch; brain; genitourinary system; respiratory system; and thymus. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 18.9), large intestine adult (RPKM 18.3) and 25 other tissues See more
Orthologs
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Genomic context

Location:
6 E3; 6 52.82 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113615428..113671987)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113638467..113695026)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene BRICK1, SCAR/WAVE actin-nucleating complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E2798 Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene STARR-seq mESC enhancer starr_17046 Neighboring gene STARR-positive B cell enhancer ABC_E6467 Neighboring gene STARR-positive B cell enhancer ABC_E6468 Neighboring gene STARR-positive B cell enhancer ABC_E3671 Neighboring gene STARR-positive B cell enhancer ABC_E9672 Neighboring gene STARR-positive B cell enhancer ABC_E1707 Neighboring gene STARR-seq mESC enhancer starr_17051 Neighboring gene STARR-positive B cell enhancer ABC_E6469 Neighboring gene TatD DNase domain containing 2 Neighboring gene microRNA 7042 Neighboring gene ghrelin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102586

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
interleukin-1 receptor-associated kinase-like 2
Names
interleukin-1 receptor-associated kinase 2c
mu-IRAK-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113553.1NP_001107025.1  interleukin-1 receptor-associated kinase-like 2 isoform b

    See identical proteins and their annotated locations for NP_001107025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is smaller compared to isoform a.
    Source sequence(s)
    AK078062, AY162379, BY110939, CJ212338
    Consensus CDS
    CCDS51873.1
    UniProtKB/Swiss-Prot
    Q8CFA1
    Related
    ENSMUSP00000086416.5, ENSMUST00000089022.9
    Conserved Domains (3) summary
    cd08795
    Location:391
    Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2
    pfam00069
    Location:160424
    Pkinase; Protein kinase domain
    cl21453
    Location:166454
    PKc_like; Protein Kinases, catalytic domain
  2. NM_172161.4NP_751893.3  interleukin-1 receptor-associated kinase-like 2 isoform a

    See identical proteins and their annotated locations for NP_751893.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and enodes the longer isoform (a).
    Source sequence(s)
    AK078062, AY162378, BY110939, CJ212338
    Consensus CDS
    CCDS20430.1
    UniProtKB/Swiss-Prot
    Q3U3K2, Q3U7F5, Q3UFX2, Q5U404, Q6YBR8, Q6YBR9, Q6YBS0, Q6YBS1, Q8C5M0, Q8CC82, Q8CEA0, Q8CFA1
    Related
    ENSMUSP00000055073.8, ENSMUST00000059286.14
    Conserved Domains (3) summary
    cd08795
    Location:391
    Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2
    pfam00069
    Location:208472
    Pkinase; Protein kinase domain
    cl21453
    Location:214502
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113615428..113671987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505325.5XP_006505388.1  interleukin-1 receptor-associated kinase-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8CFA1
    Conserved Domains (1) summary
    cl21453
    Location:71359
    PKc_like; Protein Kinases, catalytic domain