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Zzz3 zinc finger, ZZ domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 108946, updated on 12-May-2024

Summary

Official Symbol
Zzz3provided by MGI
Official Full Name
zinc finger, ZZ domain containing 3provided by MGI
Primary source
MGI:MGI:1920453
See related
Ensembl:ENSMUSG00000039068 AllianceGenome:MGI:1920453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110065C23Rik; 6430567E01Rik
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in histone H4 acetylation. Part of ATAC complex. Is expressed in ureter. Orthologous to human ZZZ3 (zinc finger ZZ-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E18 (RPKM 7.7) and 28 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Zzz3 in Genome Data Viewer
Location:
3 H3; 3 77.16 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152101110..152168463)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152395473..152462826)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm72 Neighboring gene mitoguardin 1 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene predicted gene, 57837 Neighboring gene RIKEN cDNA 3110067G11 gene Neighboring gene STARR-positive B cell enhancer ABC_E4606 Neighboring gene adenylate kinase 5 Neighboring gene expressed sequence AI115009

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ZZ-type zinc finger-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080755.2NP_001074224.1  ZZ-type zinc finger-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_001074224.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC111139, AC122529
    Consensus CDS
    CCDS38674.1
    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Related
    ENSMUSP00000101706.3, ENSMUST00000106100.9
    Conserved Domains (3) summary
    cd02341
    Location:828878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  2. NM_001287139.1NP_001274068.1  ZZ-type zinc finger-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_001274068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AC111139, BC060614, BY305239
    Consensus CDS
    CCDS71338.1
    UniProtKB/TrEMBL
    D3YTT9
    Related
    ENSMUSP00000087428.5, ENSMUST00000089982.11
    Conserved Domains (3) summary
    cd02341
    Location:827877
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:661709
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  3. NM_001346655.1NP_001333584.1  ZZ-type zinc finger-containing protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC111139, AK165882
    Consensus CDS
    CCDS84698.1
    UniProtKB/Swiss-Prot
    Q6KAQ7
    Related
    ENSMUSP00000101709.2, ENSMUST00000106103.8
    Conserved Domains (2) summary
    cd02341
    Location:327377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:161209
    Myb_DNA-binding; Myb-like DNA-binding domain
  4. NM_001355673.1NP_001342602.1  ZZ-type zinc finger-containing protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC111139, AC122529
    Consensus CDS
    CCDS38674.1
    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    152101110..152168463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319423.3XP_017174912.1  ZZ-type zinc finger-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  2. XM_006500852.5XP_006500915.1  ZZ-type zinc finger-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006500915.1

    UniProtKB/TrEMBL
    D3YTT9
    Conserved Domains (3) summary
    cd02341
    Location:827877
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:661709
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  3. XM_011239984.4XP_011238286.1  ZZ-type zinc finger-containing protein 3 isoform X3

    Conserved Domains (1) summary
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  4. XM_006500854.5XP_006500917.1  ZZ-type zinc finger-containing protein 3 isoform X5

    Conserved Domains (1) summary
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  5. XM_006500853.5XP_006500916.1  ZZ-type zinc finger-containing protein 3 isoform X4

    Conserved Domains (1) summary
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  6. XM_006500857.5XP_006500920.1  ZZ-type zinc finger-containing protein 3 isoform X8

    See identical proteins and their annotated locations for XP_006500920.1

    UniProtKB/Swiss-Prot
    Q6KAQ7
    Conserved Domains (2) summary
    cd02341
    Location:327377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:161209
    Myb_DNA-binding; Myb-like DNA-binding domain
  7. XM_006500855.5XP_006500918.1  ZZ-type zinc finger-containing protein 3 isoform X6

    Conserved Domains (2) summary
    cd02341
    Location:332382
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:166214
    Myb_DNA-binding; Myb-like DNA-binding domain
  8. XM_036162811.1XP_036018704.1  ZZ-type zinc finger-containing protein 3 isoform X4

    Conserved Domains (1) summary
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  9. XM_006500856.5XP_006500919.1  ZZ-type zinc finger-containing protein 3 isoform X7

    See identical proteins and their annotated locations for XP_006500919.1

    UniProtKB/Swiss-Prot
    Q6KAQ7
    Related
    ENSMUSP00000143693.2, ENSMUST00000200570.5
    Conserved Domains (2) summary
    cd02341
    Location:331381
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:165213
    Myb_DNA-binding; Myb-like DNA-binding domain
  10. XM_030252353.2XP_030108213.1  ZZ-type zinc finger-containing protein 3 isoform X8

    Conserved Domains (2) summary
    cd02341
    Location:327377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:161209
    Myb_DNA-binding; Myb-like DNA-binding domain
  11. XM_006500848.5XP_006500911.1  ZZ-type zinc finger-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006500911.1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Related
    ENSMUSP00000101707.2, ENSMUST00000106101.2
    Conserved Domains (3) summary
    cd02341
    Location:828878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  12. XM_030252350.2XP_030108210.1  ZZ-type zinc finger-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
  13. XM_030252352.2XP_030108212.1  ZZ-type zinc finger-containing protein 3 isoform X6

    Conserved Domains (2) summary
    cd02341
    Location:332382
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:166214
    Myb_DNA-binding; Myb-like DNA-binding domain
  14. XM_006500850.4XP_006500913.1  ZZ-type zinc finger-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006500913.1

    UniProtKB/Swiss-Prot
    Q3TMK6, Q3V189, Q6KAQ7
    Conserved Domains (3) summary
    cd02341
    Location:828878
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:662710
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam14757
    Location:343418
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

RNA

  1. XR_867209.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198416.2: Suppressed sequence

    Description
    NM_198416.2: This RefSeq was permanently suppressed because currently there is support for the protein but not for the transcript.