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Rnf169 ring finger protein 169 [ Mus musculus (house mouse) ]

Gene ID: 108937, updated on 11-Apr-2024

Summary

Official Symbol
Rnf169provided by MGI
Official Full Name
ring finger protein 169provided by MGI
Primary source
MGI:MGI:1920257
See related
Ensembl:ENSMUSG00000058761 AllianceGenome:MGI:1920257
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900057K09Rik
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and nucleosome binding activity. Predicted to be involved in cellular response to DNA damage stimulus and negative regulation of double-strand break repair. Predicted to be located in cytosol; nuclear lumen; and site of double-strand break. Is expressed in nervous system and retina. Orthologous to human RNF169 (ring finger protein 169). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 1.9), CNS E11.5 (RPKM 1.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 E2; 7 54.22 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99569461..99630537, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99920254..99981330, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene signal peptidase complex subunit 2 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1347 Neighboring gene X-ray radiation resistance associated 1 Neighboring gene predicted gene, 38405 Neighboring gene predicted gene 5115 Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19665 Neighboring gene SET translocation pseudogene Neighboring gene chordin-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-modified histone reader activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF169
Names
RING-type E3 ubiquitin transferase RNF169
NP_780597.2
XP_006507248.1
XP_006507250.1
XP_006507251.1
XP_030097842.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175388.3NP_780597.2  E3 ubiquitin-protein ligase RNF169

    See identical proteins and their annotated locations for NP_780597.2

    Status: PROVISIONAL

    Source sequence(s)
    AC113298
    Consensus CDS
    CCDS52322.1
    UniProtKB/Swiss-Prot
    E9Q7F2, Q69Z47
    Related
    ENSMUSP00000079631.4, ENSMUST00000080817.6
    Conserved Domains (1) summary
    pfam05142
    Location:76143
    DUF702; Domain of unknown function (DUF702)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99569461..99630537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507185.4XP_006507248.1  E3 ubiquitin-protein ligase RNF169 isoform X1

    Conserved Domains (1) summary
    cd16551
    Location:90127
    RING-HC_RNF169; RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
  2. XM_030241982.2XP_030097842.1  E3 ubiquitin-protein ligase RNF169 isoform X2

  3. XM_006507187.5XP_006507250.1  E3 ubiquitin-protein ligase RNF169 isoform X2

  4. XM_006507188.5XP_006507251.1  E3 ubiquitin-protein ligase RNF169 isoform X3

    Conserved Domains (2) summary
    cd00162
    Location:91126
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl17238
    Location:90127
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain