U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

B4gat1 beta-1,4-glucuronyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 108902, updated on 27-Nov-2024

Summary

Official Symbol
B4gat1provided by MGI
Official Full Name
beta-1,4-glucuronyltransferase 1provided by MGI
Primary source
MGI:MGI:1919680
See related
Ensembl:ENSMUSG00000047379 AllianceGenome:MGI:1919680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
iGAT; iGNT; B3gnt1; B3gnt6; BETA3GNT1; 1500032M01Rik
Summary
Predicted to enable glucuronosyltransferase activity. Acts upstream of or within axon guidance and protein glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and thymus. Used to study muscular dystrophy-dystroglycanopathy type B1. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A13. Orthologous to human B4GAT1 (beta-1,4-glucuronyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 31.2), cerebellum adult (RPKM 27.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See B4gat1 in Genome Data Viewer
Location:
19; 19 A
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5088854..5091162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5038826..5041134)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 29 (nucleoside transporters), member 2 Neighboring gene predicted gene, 30581 Neighboring gene nuclear encoded tRNA serine 6 (anticodon GCT) Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5041192-5041379 Neighboring gene breast cancer metastasis-suppressor 1 Neighboring gene Ras and Rab interactor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Brms1

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in poly-N-acetyllactosamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-1,4-glucuronyltransferase 1
Names
I-beta-1,3-N-acetylglucosaminyltransferase
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
poly-N-acetyllactosamine extension enzyme
NP_780592.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175383.2NP_780592.1  beta-1,4-glucuronyltransferase 1

    See identical proteins and their annotated locations for NP_780592.1

    Status: VALIDATED

    Source sequence(s)
    AK158899, AV344651
    Consensus CDS
    CCDS29446.1
    UniProtKB/Swiss-Prot
    Q3TY43, Q8BJH9, Q8BWP8, Q99LW7
    Related
    ENSMUSP00000062016.7, ENSMUST00000053705.8
    Conserved Domains (1) summary
    pfam13896
    Location:94408
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5088854..5091162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)