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Aif1l allograft inflammatory factor 1-like [ Mus musculus (house mouse) ]

Gene ID: 108897, updated on 7-May-2024

Summary

Official Symbol
Aif1lprovided by MGI
Official Full Name
allograft inflammatory factor 1-likeprovided by MGI
Primary source
MGI:MGI:1919598
See related
Ensembl:ENSMUSG00000001864 AllianceGenome:MGI:1919598
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iba2; 2810003C17Rik
Summary
Predicted to enable actin filament binding activity and calcium ion binding activity. Predicted to be involved in actin filament bundle assembly and ruffle assembly. Predicted to be located in actin cytoskeleton and focal adhesion. Predicted to be part of protein-containing complex. Predicted to colocalize with actin filament and ruffle membrane. Is expressed in several structures, including cranium; genitourinary system; nervous system; otocyst; and stomach. Orthologous to human AIF1L (allograft inflammatory factor 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 41.5), CNS E11.5 (RPKM 11.8) and 9 other tissues See more
Orthologs
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Genomic context

See Aif1l in Genome Data Viewer
Location:
2 B; 2 21.95 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31840315..31863454)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31950303..31973442)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10093 Neighboring gene fibrinogen C domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_04163 Neighboring gene laminin gamma 3 Neighboring gene nucleoporin 214 Neighboring gene BTG3 associated nuclear protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_04165 Neighboring gene predicted gene 13609

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC30545

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
allograft inflammatory factor 1-like
Names
ionized calcium binding adapter molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145144.1NP_660126.1  allograft inflammatory factor 1-like

    See identical proteins and their annotated locations for NP_660126.1

    Status: PROVISIONAL

    Source sequence(s)
    BC024599
    Consensus CDS
    CCDS15904.1
    UniProtKB/Swiss-Prot
    Q8C150, Q9EQX4
    UniProtKB/TrEMBL
    A0A0A6YWH2
    Related
    ENSMUSP00000001920.8, ENSMUST00000001920.13
    Conserved Domains (1) summary
    PTZ00184
    Location:47115
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    31840315..31863454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)