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GPR83 G protein-coupled receptor 83 [ Homo sapiens (human) ]

Gene ID: 10888, updated on 1-Jun-2020

Summary

Official Symbol
GPR83provided by HGNC
Official Full Name
G protein-coupled receptor 83provided by HGNC
Primary source
HGNC:HGNC:4523
See related
Ensembl:ENSG00000123901 MIM:605569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIR; GPR72
Expression
Biased expression in brain (RPKM 1.9), thyroid (RPKM 1.3) and 4 other tissues See more
Orthologs

Genomic context

See GPR83 in Genome Data Viewer
Location:
11q21
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (94377316..94401419, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94110477..94134585, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369435 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene microRNA 548l Neighboring gene ankyrin repeat domain 49

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cilium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 83
Names
G-protein coupled receptor 72
glucocorticoid induced receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330345.2NP_001317274.1  probable G-protein coupled receptor 83 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AP000765
    Consensus CDS
    CCDS81616.1
    UniProtKB/TrEMBL
    F5GZ43
    Related
    ENSP00000441550.1, ENST00000539203.2
    Conserved Domains (1) summary
    pfam00001
    Location:88303
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_016540.4NP_057624.3  probable G-protein coupled receptor 83 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057624.3

    Status: VALIDATED

    Source sequence(s)
    AB040973, AI914177, AK315161, AP000765, DA317535
    Consensus CDS
    CCDS8297.1
    UniProtKB/Swiss-Prot
    Q9NYM4
    Related
    ENSP00000243673.2, ENST00000243673.7
    Conserved Domains (1) summary
    cd15389
    Location:72356
    7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    94377316..94401419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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