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NPFFR2 neuropeptide FF receptor 2 [ Homo sapiens (human) ]

Gene ID: 10886, updated on 21-Dec-2019

Summary

Official Symbol
NPFFR2provided by HGNC
Official Full Name
neuropeptide FF receptor 2provided by HGNC
Primary source
HGNC:HGNC:4525
See related
Ensembl:ENSG00000056291 MIM:607449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR74; NPFF2; NPGPR; HLWAR77
Summary
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Expression
Biased expression in placenta (RPKM 1.4), thyroid (RPKM 0.2) and 7 other tissues See more
Orthologs

Genomic context

See NPFFR2 in Genome Data Viewer
Location:
4q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (72031804..72148201)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (72897521..73013918)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 163 Neighboring gene VISTA enhancer hs2570 Neighboring gene GC vitamin D binding protein Neighboring gene Sharpr-MPRA regulatory region 3382 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 67

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
opioid receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of abiotic stimulus TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide FF receptor 2
Names
G-protein coupled receptor 74
G-protein coupled receptor HLWAR77
neuropeptide FF 2
neuropeptide G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144756.1NP_001138228.1  neuropeptide FF receptor 2 isoform 3

    See identical proteins and their annotated locations for NP_001138228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC106051, AC106898, AF119815, AF236083, AK290937, CN285250
    Consensus CDS
    CCDS47072.1
    UniProtKB/Swiss-Prot
    Q9Y5X5
    UniProtKB/TrEMBL
    A0PJM9
    Related
    ENSP00000379321.1, ENST00000395999.5
    Conserved Domains (2) summary
    pfam00001
    Location:65336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56178
    7tm_4; Olfactory receptor
  2. NM_004885.2NP_004876.2  neuropeptide FF receptor 2 isoform 1

    See identical proteins and their annotated locations for NP_004876.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC106051, AF119815, CN285250
    Consensus CDS
    CCDS3551.1
    UniProtKB/Swiss-Prot
    Q9Y5X5
    Related
    ENSP00000307822.6, ENST00000308744.10
    Conserved Domains (2) summary
    pfam00001
    Location:164435
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:155277
    7tm_4; Olfactory receptor
  3. NM_053036.2NP_444264.1  neuropeptide FF receptor 2 isoform 2

    See identical proteins and their annotated locations for NP_444264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR that causes translation initiation at a downstream AUG, and results an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC106051, AC106898, AF119815, AK290937, CN285250
    Consensus CDS
    CCDS3552.1
    UniProtKB/Swiss-Prot
    Q9Y5X5
    UniProtKB/TrEMBL
    A0PJM9
    Related
    ENSP00000351599.3, ENST00000358749.3
    Conserved Domains (2) summary
    pfam00001
    Location:62333
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:53175
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    72031804..72148201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531554.2XP_011529856.1  neuropeptide FF receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011529856.1

    Conserved Domains (2) summary
    pfam00001
    Location:1217
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:1559
    7tm_4; Olfactory receptor
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