Mtrf1l mitochondrial translational release factor 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtrf1lprovided by MGI
Official Full Name: mitochondrial translational release factor 1-likeprovided by MGI
Primary source: MGI:MGI:1918830
See related: Ensembl:ENSMUSG00000019774 AllianceGenome:MGI:1918830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9130004K12Rik
Summary: Predicted to enable translation release factor activity. Predicted to be involved in mitochondrial translational termination. Predicted to act upstream of or within translation. Located in mitochondrion. Orthologous to human MTRF1L (mitochondrial translation release factor 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.0), limb E14.5 (RPKM 1.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 A1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (5760151..5775015, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (5811119..5825015, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Homology

Homologs of the Mtrf1l gene: The Mtrf1l gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 348 organisms have orthologs with human gene Mtrf1l
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables translation release factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial translational termination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational termination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptide chain release factor 1-like, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175374.3 → NP_780583.1 peptide chain release factor 1-like, mitochondrial precursor

See identical proteins and their annotated locations for NP_780583.1

Status: VALIDATED

Source sequence(s)

AI510282, AK036424, AK078897

Consensus CDS

CCDS56684.1

UniProtKB/Swiss-Prot

Q8BJU9

UniProtKB/TrEMBL

A0A8C6I5G4

Related

ENSMUSP00000019908.9, ENSMUST00000019908.9

Conserved Domains (3) summary

COG1186
Location:123 → 355

PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]

pfam00472
Location:224 → 329

RF-1; RF-1 domain

pfam03462
Location:57 → 214

PCRF; PCRF domain