Format

Send to:

Choose Destination

WDR3 WD repeat domain 3 [ Homo sapiens (human) ]

Gene ID: 10885, updated on 8-Aug-2021

Summary

Official Symbol
WDR3provided by HGNC
Official Full Name
WD repeat domain 3provided by HGNC
Primary source
HGNC:HGNC:12755
See related
Ensembl:ENSG00000065183 MIM:604737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIP2; UTP12
Summary
This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 13.4), appendix (RPKM 7.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See WDR3 in Genome Data Viewer
Location:
1p12
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (117929739..117966543)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (118472362..118509166)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378929 Neighboring gene ganglioside induced differentiation associated protein 2 Neighboring gene Sharpr-MPRA regulatory region 13757 Neighboring gene sperm associated antigen 17 Neighboring gene uncharacterized LOC105378930 Neighboring gene RNA, 5S ribosomal pseudogene 56

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, WD repeat domain 3 (WDR3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with WDR3 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TENT5C

Homology

Clone Names

  • FLJ12796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 3
Names
dJ776P7.2 (WD repeat domain 3)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006784.3NP_006775.1  WD repeat-containing protein 3

    See identical proteins and their annotated locations for NP_006775.1

    Status: REVIEWED

    Source sequence(s)
    AA258068, AF083217, AK292438, AL121993, BP281064, BU685597
    Consensus CDS
    CCDS898.1
    UniProtKB/Swiss-Prot
    Q9UNX4
    UniProtKB/TrEMBL
    Q5TDG3
    Related
    ENSP00000308179.4, ENST00000349139.6
    Conserved Domains (5) summary
    COG2319
    Location:85698
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:407703
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04003
    Location:804905
    Utp12; Dip2/Utp12 Family
    sd00039
    Location:462494
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:47226
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    117929739..117966543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center