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Ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 108837, updated on 3-Jun-2018
Official Symbol
Ibtkprovided by MGI
Official Full Name
inhibitor of Bruton agammaglobulinemia tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1918677
See related
Ensembl:ENSMUSG00000035941 Vega:OTTMUSG00000045033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BTKI; AA409502; mKIAA1417; 5430411K16Rik
Expression
Ubiquitous expression in bladder adult (RPKM 7.6), CNS E11.5 (RPKM 6.3) and 28 other tissues See more
Orthologs
See Ibtk in Genome Data Viewer
Location:
9; 9 E3.1
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (85687360..85750435, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (85580963..85637766, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 pseudogene Neighboring gene terminal nucleotidyltransferase 5A Neighboring gene quinolinate phosphoribosyltransferase pseudogene Neighboring gene ribosomal protein L7A pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
inhibitor of Bruton tyrosine kinase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081282.2NP_001074751.1  inhibitor of Bruton tyrosine kinase isoform 1

    See identical proteins and their annotated locations for NP_001074751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AK031796, BB639555, BC137798, BP760552
    Consensus CDS
    CCDS40712.1
    UniProtKB/Swiss-Prot
    Q6ZPR6
    Related
    ENSMUSP00000041145.8, OTTMUSP00000066062, ENSMUST00000039213.14, OTTMUST00000118333
    Conserved Domains (8) summary
    smart00225
    Location:770872
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd00204
    Location:47135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:872919
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:247299
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:562643
    BTB; BTB/POZ domain
    pfam12796
    Location:25116
    Ank_2; Ankyrin repeats (3 copies)
    pfam13540
    Location:232260
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    sd00045
    Location:5182
    ANK; ANK repeat [structural motif]
  2. NM_175371.3NP_780580.2  inhibitor of Bruton tyrosine kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an in-frame downstream translation start site, compared to variant 1. It encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC155934
    Conserved Domains (2) summary
    cd14821
    Location:312359
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:280
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    85687360..85750435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510765.3XP_006510828.1  inhibitor of Bruton tyrosine kinase isoform X1

    Conserved Domains (8) summary
    smart00225
    Location:769871
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd00204
    Location:47135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:871918
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:247299
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:561642
    BTB; BTB/POZ domain
    pfam12796
    Location:25116
    Ank_2; Ankyrin repeats (3 copies)
    pfam13540
    Location:232260
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    sd00045
    Location:5182
    ANK; ANK repeat [structural motif]
  2. XM_006510766.3XP_006510829.1  inhibitor of Bruton tyrosine kinase isoform X2

    Conserved Domains (2) summary
    cd14821
    Location:312359
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:280
    BTB; BTB/POZ domain
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