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CEACAM8 CEA cell adhesion molecule 8 [ Homo sapiens (human) ]

Gene ID: 1088, updated on 20-Jan-2022

Summary

Official Symbol
CEACAM8provided by HGNC
Official Full Name
CEA cell adhesion molecule 8provided by HGNC
Primary source
HGNC:HGNC:1820
See related
Ensembl:ENSG00000124469 MIM:615747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD67; CGM6; CD66b; NCA-95
Summary
Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward bone marrow (RPKM 58.6) See more
Orthologs
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Genomic context

See CEACAM8 in Genome Data Viewer
Location:
19q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42580243..42595157, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43084395..43099076, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIPE antisense RNA 1 Neighboring gene uncharacterized LOC105372407 Neighboring gene CEA cell adhesion molecule 1 Neighboring gene CEA cell adhesion molecule pseudogene 2 Neighboring gene CEA cell adhesion molecule pseudogene 1 Neighboring gene CEA cell adhesion molecule pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 8
Names
CD67 antigen
carcinoembryonic antigen CGM6
carcinoembryonic antigen gene family member 6
carcinoembryonic antigen related cell adhesion molecule 8
non-specific cross-reacting antigen NCA-95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001816.4NP_001807.2  carcinoembryonic antigen-related cell adhesion molecule 8 precursor

    See identical proteins and their annotated locations for NP_001807.2

    Status: VALIDATED

    Source sequence(s)
    AK297012, BC026263, DA464901
    Consensus CDS
    CCDS12610.1
    UniProtKB/Swiss-Prot
    P31997
    UniProtKB/TrEMBL
    B4DLI3, Q0Z7S6
    Related
    ENSP00000244336.5, ENST00000244336.10
    Conserved Domains (3) summary
    pfam13895
    Location:239307
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:146234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42580243..42595157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026195.1XP_016881684.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X3

    UniProtKB/Swiss-Prot
    P31997
    UniProtKB/TrEMBL
    Q0Z7S6
    Conserved Domains (3) summary
    pfam13895
    Location:239307
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:146234
    Ig; Immunoglobulin domain
  2. XM_011526341.1XP_011524643.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X6

    See identical proteins and their annotated locations for XP_011524643.1

    Conserved Domains (3) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    cl11960
    Location:146234
    Ig; Immunoglobulin domain
  3. XM_017026198.1XP_016881687.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X6

    Conserved Domains (3) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    cl11960
    Location:146234
    Ig; Immunoglobulin domain
  4. XM_017026196.1XP_016881685.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X4

  5. XM_017026194.1XP_016881683.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X2

  6. XM_011526340.2XP_011524642.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X1

    Conserved Domains (4) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244312
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146234
    Ig; Immunoglobulin domain
  7. XM_017026197.2XP_016881686.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X5

  8. XM_011526342.1XP_011524644.1  carcinoembryonic antigen-related cell adhesion molecule 8 isoform X6

    See identical proteins and their annotated locations for XP_011524644.1

    Conserved Domains (3) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:157233
    IG_like; Immunoglobulin like
    cl11960
    Location:146234
    Ig; Immunoglobulin domain
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