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Mex3b mex3 RNA binding family member B [ Mus musculus (house mouse) ]

Gene ID: 108797, updated on 12-May-2024

Summary

Official Symbol
Mex3bprovided by MGI
Official Full Name
mex3 RNA binding family member Bprovided by MGI
Primary source
MGI:MGI:1918252
See related
Ensembl:ENSMUSG00000057706 AllianceGenome:MGI:1918252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rkhd3; M-04814; mKIAA2009; 4931439A04Rik
Summary
Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including positive regulation of GTPase activity; positive regulation of phagocytosis; and protein localization to cell cortex. Predicted to be located in P-body; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cartilage; cranium; and reproductive system. Orthologous to human MEX3B (mex-3 RNA binding family member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 55.4), CNS E14 (RPKM 46.2) and 14 other tissues See more
Orthologs
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Genomic context

See Mex3b in Genome Data Viewer
Location:
7 D3; 7 47.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (82516541..82520784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (82867333..82871576)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29796 Neighboring gene STARR-seq mESC enhancer starr_19392 Neighboring gene predicted gene, 36584 Neighboring gene RIKEN cDNA 1700010L04 gene Neighboring gene STARR-seq mESC enhancer starr_19393 Neighboring gene STARR-positive B cell enhancer ABC_E10448 Neighboring gene RIKEN cDNA 4933430H16 gene Neighboring gene STARR-seq mESC enhancer starr_19395 Neighboring gene predicted gene, 45992 Neighboring gene STARR-seq mESC enhancer starr_19396 Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA-binding protein MEX3B
Names
RING finger and KH domain-containing protein 3
mex3 homolog B
ring finger and KH domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175366.3NP_780575.2  RNA-binding protein MEX3B

    Status: VALIDATED

    Source sequence(s)
    AC122736
    Consensus CDS
    CCDS52286.1
    UniProtKB/Swiss-Prot
    Q2VPR1, Q69Z36, Q6NX84, Q8K2G2
    UniProtKB/TrEMBL
    F8WJD6
    Related
    ENSMUSP00000082168.5, ENSMUST00000082237.7
    Conserved Domains (3) summary
    smart00322
    Location:167232
    KH; K homology RNA-binding domain
    cd00105
    Location:74134
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd16721
    Location:523565
    RING-HC_MEX3B; RING finger, HC subclass, found in RNA-binding protein MEX3B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    82516541..82520784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)