U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oxsr1 oxidative-stress responsive 1 [ Mus musculus (house mouse) ]

Gene ID: 108737, updated on 9-May-2024

Summary

Official Symbol
Oxsr1provided by MGI
Official Full Name
oxidative-stress responsive 1provided by MGI
Primary source
MGI:MGI:1917378
See related
Ensembl:ENSMUSG00000036737 AllianceGenome:MGI:1917378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Osr1; mKIAA1101; 2210022N24Rik; 2810422B09Rik
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; chemokine (C-C motif) ligand 21 signaling pathway; and positive regulation of T cell chemotaxis. Predicted to be located in cytosol. Is expressed in loop of Henle distal straight tubule and metanephros. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.9), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Oxsr1 in Genome Data Viewer
Location:
9 F3; 9 71.33 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119067498..119154475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119238432..119322684, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 13 Neighboring gene STARR-seq mESC enhancer starr_25469 Neighboring gene solute carrier family 22 (organic cation transporter), member 13b Neighboring gene STARR-positive B cell enhancer ABC_E1119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119231914-119232305 Neighboring gene STARR-positive B cell enhancer ABC_E11425 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene acetyl-Coenzyme A acyltransferase 1A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hypotonic response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
involved_in chemokine (C-C motif) ligand 21 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of potassium ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in osmosensory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative stress-responsive 1 protein
NP_001346511.1
NP_598746.2
XP_030099862.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359582.1NP_001346511.1  serine/threonine-protein kinase OSR1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC128702
    Consensus CDS
    CCDS57714.1
    UniProtKB/Swiss-Prot
    Q6P9R2, Q8BVZ9, Q8C0B9
    UniProtKB/TrEMBL
    Q6ZPX7
    Conserved Domains (1) summary
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  2. NM_133985.2NP_598746.2  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_598746.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC128702, BC060645
    Consensus CDS
    CCDS57714.1
    UniProtKB/Swiss-Prot
    Q6P9R2, Q8BVZ9, Q8C0B9
    UniProtKB/TrEMBL
    Q6ZPX7
    Related
    ENSMUSP00000042155.5, ENSMUST00000040853.11
    Conserved Domains (1) summary
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RNA

  1. NR_045693.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC128702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119067498..119154475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244002.2XP_030099862.1  serine/threonine-protein kinase OSR1 isoform X1

    Conserved Domains (2) summary
    pfam12202
    Location:242299
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain