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ME3 malic enzyme 3 [ Homo sapiens (human) ]

Gene ID: 10873, updated on 11-Sep-2019

Summary

Official Symbol
ME3provided by HGNC
Official Full Name
malic enzyme 3provided by HGNC
Primary source
HGNC:HGNC:6985
See related
Ensembl:ENSG00000151376 MIM:604626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NADP-ME
Summary
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 4.2), fat (RPKM 4.1) and 25 other tissues See more
Orthologs

Genomic context

See ME3 in Genome Data Viewer
Location:
11q14.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (86441108..86674746, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (86152150..86383678, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 81 Neighboring gene PTP4A1 pseudogene 6 Neighboring gene ME3 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 8285 Neighboring gene uncharacterized LOC102724775

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34862

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
cofactor binding TAS
Traceable Author Statement
more info
PubMed 
malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
malic enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malic enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aerobic respiration TAS
Traceable Author Statement
more info
PubMed 
malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxygen metabolic process TAS
Traceable Author Statement
more info
PubMed 
pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyruvate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NADP-dependent malic enzyme, mitochondrial
Names
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
malic enzyme 3, NADP(+)-dependent, mitochondrial
malic enzyme, NADP+-dependent, mitochondrial
mitochondrial NADP(+)-dependent malic enzyme 3
pyruvic-malic carboxylase
NP_001014811.1
NP_001155058.1
NP_001338863.1
NP_006671.2
XP_016872625.1
XP_016872626.1
XP_016872627.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014811.1NP_001014811.1  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_001014811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AA403046, AI198184, AI948779, AY424278, BC022472
    Consensus CDS
    CCDS8277.1
    UniProtKB/Swiss-Prot
    Q16798
    UniProtKB/TrEMBL
    Q6TCH8
    Related
    ENSP00000376998.2, ENST00000393324.7
    Conserved Domains (1) summary
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional
  2. NM_001161586.1NP_001155058.1  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_001155058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR and encodes the same protein, as compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AI560417, AK313695, BQ882896, CB306059, DC388623
    Consensus CDS
    CCDS8277.1
    UniProtKB/Swiss-Prot
    Q16798
    UniProtKB/TrEMBL
    B2R995
    Related
    ENSP00000440246.1, ENST00000543262.5
    Conserved Domains (1) summary
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional
  3. NM_001351934.1NP_001338863.1  NADP-dependent malic enzyme, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR and encodes the same protein, as compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AP001148, AP001831, AP002492
    Consensus CDS
    CCDS8277.1
    Conserved Domains (1) summary
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional
  4. NM_006680.2NP_006671.2  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_006671.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2-4 all encode the same protein.
    Source sequence(s)
    AA449933, AI198184, AI948779, AY424278, BC022472, BM906572, X79440
    Consensus CDS
    CCDS8277.1
    UniProtKB/Swiss-Prot
    Q16798
    UniProtKB/TrEMBL
    Q6TCH8
    Conserved Domains (1) summary
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional

RNA

  1. NR_147828.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001148, AP001831, AP002492
  2. NR_147829.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001148, AP001831, AP002492
  3. NR_147830.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001148, AP001831, AP002492
  4. NR_147831.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001148, AP001831, AP002492

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    86441108..86674746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017136.1XP_016872625.1  NADP-dependent malic enzyme, mitochondrial isoform X1

  2. XM_017017138.1XP_016872627.1  NADP-dependent malic enzyme, mitochondrial isoform X3

    Conserved Domains (3) summary
    cd05312
    Location:104381
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:1387
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:194
    malic; Malic enzyme, N-terminal domain
  3. XM_017017137.1XP_016872626.1  NADP-dependent malic enzyme, mitochondrial isoform X2

RNA

  1. XR_001747749.2 RNA Sequence

  2. XR_001747741.2 RNA Sequence

  3. XR_001747739.2 RNA Sequence

  4. XR_001747740.1 RNA Sequence

  5. XR_001747744.2 RNA Sequence

  6. XR_001747743.2 RNA Sequence

  7. XR_001747747.2 RNA Sequence

  8. XR_001747738.2 RNA Sequence

  9. XR_001747736.2 RNA Sequence

  10. XR_001747737.2 RNA Sequence

  11. XR_949766.3 RNA Sequence

  12. XR_001747742.2 RNA Sequence

  13. XR_949760.2 RNA Sequence

  14. XR_001747745.1 RNA Sequence

  15. XR_001747746.1 RNA Sequence

  16. XR_949761.3 RNA Sequence

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