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CD300C CD300c molecule [ Homo sapiens (human) ]

Gene ID: 10871, updated on 21-Dec-2019

Summary

Official Symbol
CD300Cprovided by HGNC
Official Full Name
CD300c moleculeprovided by HGNC
Primary source
HGNC:HGNC:19320
See related
Ensembl:ENSG00000167850 MIM:606786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1
Summary
The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in lung (RPKM 2.9), appendix (RPKM 2.6) and 19 other tissues See more
Orthologs

Genomic context

See CD300C in Genome Data Viewer
Location:
17q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74534359..74546115, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72537204..72542310, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CD300a molecule Neighboring gene CD300 molecule like family member b Neighboring gene uncharacterized LOC107985074 Neighboring gene CD300H molecule (gene/pseudogene) Neighboring gene CD300 molecule like family member d Neighboring gene chromosome 17 open reading frame 77

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CMRF35-like molecule 6
Names
CD300 antigen-like family member C
CD300c antigen
CMRF35 antigen
CMRF35 leukocyte immunoglobulin-like receptor
CMRF35A leukocyte immunoglobulin-like receptor
immunoglobulin superfamily member 16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006678.5NP_006669.1  CMRF35-like molecule 6 precursor

    See identical proteins and their annotated locations for NP_006669.1

    Status: VALIDATED

    Source sequence(s)
    AC079325, BC022279, BF508242
    Consensus CDS
    CCDS11701.1
    UniProtKB/Swiss-Prot
    Q08708
    Related
    ENSP00000329507.1, ENST00000330793.2
    Conserved Domains (2) summary
    cd05716
    Location:30119
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    cl11960
    Location:95183
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74534359..74546115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024033.2XP_016879522.1  CMRF35-like molecule 6 isoform X1

  2. XM_017024034.2XP_016879523.1  CMRF35-like molecule 6 isoform X2

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