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HCST hematopoietic cell signal transducer [ Homo sapiens (human) ]

Gene ID: 10870, updated on 7-Jun-2020

Summary

Official Symbol
HCSTprovided by HGNC
Official Full Name
hematopoietic cell signal transducerprovided by HGNC
Primary source
HGNC:HGNC:16977
See related
Ensembl:ENSG00000126264 MIM:604089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP10; KAP10; PIK3AP
Summary
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 39.5), spleen (RPKM 20.3) and 12 other tissues See more
Orthologs

Genomic context

See HCST in Genome Data Viewer
Location:
19q13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35902365..35904377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36393382..36395173)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 402, pseudogene Neighboring gene NFKB inhibitor delta Neighboring gene transmembrane immune signaling adaptor TYROBP Neighboring gene leucine rich repeat and fibronectin type III domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of HCST PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZP586C1522

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hematopoietic cell signal transducer
Names
DNAX-activation protein 10
kinase assoc pro of ~10kDa
kinase assoc protein
membrane protein DAP10
phosphoinositide-3-kinase adaptor protein
transmembrane adapter protein KAP10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007469.2NP_001007470.1  hematopoietic cell signal transducer isoform 2 precursor

    See identical proteins and their annotated locations for NP_001007470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AF072844, AL050163
    Consensus CDS
    CCDS46057.1
    UniProtKB/Swiss-Prot
    Q9UBK5
    Related
    ENSP00000400516.1, ENST00000437550.2
    Conserved Domains (1) summary
    pfam07213
    Location:192
    DAP10; DAP10 membrane protein
  2. NM_014266.4NP_055081.1  hematopoietic cell signal transducer isoform 1 precursor

    See identical proteins and their annotated locations for NP_055081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AD000864, AL050163
    Consensus CDS
    CCDS32998.1
    UniProtKB/Swiss-Prot
    Q9UBK5
    Related
    ENSP00000246551.3, ENST00000246551.9
    Conserved Domains (1) summary
    pfam07213
    Location:193
    DAP10; DAP10 membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35902365..35904377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026193.1XP_016881682.1  hematopoietic cell signal transducer isoform X1

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