Format

Send to:

Choose Destination

CEACAM7 CEA cell adhesion molecule 7 [ Homo sapiens (human) ]

Gene ID: 1087, updated on 5-Jan-2022

Summary

Official Symbol
CEACAM7provided by HGNC
Official Full Name
CEA cell adhesion molecule 7provided by HGNC
Primary source
HGNC:HGNC:1819
See related
Ensembl:ENSG00000007306 MIM:619160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGM2
Summary
This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward colon (RPKM 448.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CEACAM7 in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41673303..41688270, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42177231..42192199, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 7
Names
carcinoembryonic antigen CGM2
carcinoembryonic antigen gene family member 2
carcinoembryonic antigen related cell adhesion molecule 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291485.2NP_001278414.1  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

    See identical proteins and their annotated locations for NP_001278414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC243960, AK292213
    Consensus CDS
    CCDS12583.1
    UniProtKB/Swiss-Prot
    Q14002
    Related
    ENSP00000385932.1, ENST00000401731.6
    Conserved Domains (2) summary
    cd05774
    Location:38141
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:147234
    Ig; Immunoglobulin domain
  2. NM_006890.5NP_008821.2  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

    See identical proteins and their annotated locations for NP_008821.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC243960, BC121132, DC345133
    Consensus CDS
    CCDS12583.1
    UniProtKB/Swiss-Prot
    Q14002
    Related
    ENSP00000006724.3, ENST00000006724.7
    Conserved Domains (2) summary
    cd05774
    Location:38141
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:147234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41673303..41688270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187620.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    4498..8698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center