U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CEACAM7 CEA cell adhesion molecule 7 [ Homo sapiens (human) ]

Gene ID: 1087, updated on 25-Nov-2025
Official Symbol
CEACAM7provided by HGNC
Official Full Name
CEA cell adhesion molecule 7provided by HGNC
Primary source
HGNC:HGNC:1819
See related
Ensembl:ENSG00000007306 MIM:619160; AllianceGenome:HGNC:1819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGM2
Summary
This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward colon (RPKM 448.6) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See CEACAM7 in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41673303..41688270, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44492598..44507564, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42177231..42192199, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10670 Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Opa proteins of pathogenic neisseriae initiate Src kinase-dependent or lipid raft-mediated uptake via distinct human carcinoembryonic antigen-related cell adhesion molecule isoforms. Schmitter T, et al. Infect Immun, 2007 Aug. PMID 17517873, Free PMC Article
  2. Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding. Popp A, et al. Cell Microbiol, 1999 Sep. PMID 11207550
  3. Carcinoembryonic gene member 2 mRNA expression as a marker to detect circulating enterocytes in the blood of colorectal cancer patients. Douard R, et al. Surgery, 2001 May. PMID 11331451
  4. Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. Yoshida K, et al. Cancer Sci, 2003 Mar. PMID 12824920, Free PMC Article
  5. Interferon-gamma tempers the expression of carcinoembryonic antigen family molecules in human colon cells: a possible role in innate mucosal defence. Fahlgren A, et al. Scand J Immunol, 2003 Dec. PMID 14636419

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients.
    Title: CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients.
  2. CEACAM7 expression is significantly upregulated in human masticatory mucosa during wound healing
    Title: Human gingiva transcriptome during wound healing.
  3. crystal structure of the N-terminal dimerization domain of CEACAM has been determined at 1.47 A resolution
    Title: Structure of the N-terminal dimerization domain of CEACAM7.
  4. High CEACAM7 is associated with gastric carcinoma.
    Title: Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA.
  5. CEACAM-7 expression is significantly decreased in rectal cancer; a potential tumor marker
    Title: CEACAM-7: a predictive marker for rectal cancer recurrence.
  6. CGM2 RT-PCR assay provides no specific prognostic information and cannot be used as a decision criterion for adjuvant therapy after colorectal cancer surgery.
    Title: Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cell adhesion molecule CEACAM7
Names
carcinoembryonic antigen CGM2
carcinoembryonic antigen gene family member 2
carcinoembryonic antigen related cell adhesion molecule 7
NP_001278414.1

Length

  • 265
NP_008821.2

Length

  • 265

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291485.2 → NP_001278414.1  cell adhesion molecule CEACAM7 preproprotein

    See identical proteins and their annotated locations for NP_001278414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC243960, AK292213
    Consensus CDS
    CCDS12583.1
    UniProtKB/Swiss-Prot
    A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
    UniProtKB/TrEMBL
    B4DKM4
    Related
    ENSP00000385932.1, ENST00000401731.6
    Conserved Domains (2) summary
    cd05774
    Location:38 → 141
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:147 → 234
    Ig; Immunoglobulin domain

  2. NM_006890.5 → NP_008821.2  cell adhesion molecule CEACAM7 preproprotein

    See identical proteins and their annotated locations for NP_008821.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC243960, BC121132, DC345133
    Consensus CDS
    CCDS12583.1
    UniProtKB/Swiss-Prot
    A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
    UniProtKB/TrEMBL
    B4DKM4
    Related
    ENSP00000006724.3, ENST00000006724.7
    Conserved Domains (2) summary
    cd05774
    Location:38 → 141
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:147 → 234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41673303..41688270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    4498..8698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44492598..44507564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14002.2 GenPept UniProtKB/Swiss-Prot:Q14002

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous