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USP19 ubiquitin specific peptidase 19 [ Homo sapiens (human) ]

Gene ID: 10869, updated on 1-Jun-2020

Summary

Official Symbol
USP19provided by HGNC
Official Full Name
ubiquitin specific peptidase 19provided by HGNC
Primary source
HGNC:HGNC:12617
See related
Ensembl:ENSG00000172046 MIM:614471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZMYND9
Summary
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in testis (RPKM 12.9), thyroid (RPKM 11.3) and 25 other tissues See more
Orthologs

Genomic context

See USP19 in Genome Data Viewer
Location:
3p21.31
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (49108046..49120938, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49145479..49158371, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene glutamine rich 1 Neighboring gene RNA, 7SL, cytoplasmic 182, pseudogene Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene microRNA 6890 Neighboring gene laminin subunit beta 2 Neighboring gene CRISPRi-validated cis-regulatory element chr3.2093

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Lys48-specific deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of skeletal muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
 
response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
PubMed 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 19
Names
deubiquitinating enzyme 19
ubiquitin specific protease 19
ubiquitin thioesterase 19
ubiquitin thiolesterase 19
ubiquitin-specific-processing protease 19
zinc finger MYND domain-containing protein 9
NP_001186089.1
NP_001186090.1
NP_001186091.1
NP_001338027.1
NP_001338028.1
NP_001338029.1
NP_001338030.1
NP_001338031.1
NP_001338032.1
NP_001338033.1
NP_001338034.1
NP_001338035.1
NP_001338036.1
NP_001338037.1
NP_006668.1
XP_005264880.1
XP_005264881.1
XP_005264882.1
XP_005264883.1
XP_005264884.1
XP_005264886.1
XP_005264887.1
XP_006713009.1
XP_006713010.1
XP_006713011.1
XP_006713012.1
XP_006713014.1
XP_006713015.1
XP_006713016.1
XP_016861105.1
XP_016861106.1
XP_016861108.1
XP_016861110.1
XP_016861113.1
XP_016861114.1
XP_016861115.1
XP_016861116.1
XP_016861117.1
XP_016861118.1
XP_016861122.1
XP_016861124.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054716.1 RefSeqGene

    Range
    5001..17893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199160.1NP_001186089.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK294756, BC146752, DC323791, DC332671
    Consensus CDS
    CCDS56254.1
    UniProtKB/Swiss-Prot
    O94966
    Related
    ENSP00000401197.2, ENST00000434032.6
    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:389485
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11561313
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:599785
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:892934
    zf-MYND; MYND finger
    pfam14533
    Location:799858
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:476596
    USP19_linker; Linker region of USP19 deubiquitinase
  2. NM_001199161.1NP_001186090.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS and an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has an internal additional 2 aa and a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC014934, BC048269, BC142660, DC323791, DC332671
    Consensus CDS
    CCDS56255.1
    UniProtKB/Swiss-Prot
    O94966
    Related
    ENSP00000395260.1, ENST00000417901.5
    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:389485
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11581315
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:601787
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:894936
    zf-MYND; MYND finger
    pfam14533
    Location:801860
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:476598
    USP19_linker; Linker region of USP19 deubiquitinase
  3. NM_001199162.1NP_001186091.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the CDS and an alternate 3' exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK300425, BC014934, BC048269, DC323791, DC332671
    Consensus CDS
    CCDS56256.1
    UniProtKB/Swiss-Prot
    O94966
    Related
    ENSP00000400090.1, ENST00000453664.5
    Conserved Domains (6) summary
    cd06466
    Location:379475
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11461303
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:589775
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:882924
    zf-MYND; MYND finger
    pfam14533
    Location:789848
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:466586
    USP19_linker; Linker region of USP19 deubiquitinase
  4. NM_001351098.1NP_001338027.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:376472
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:463585
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:5831305
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  5. NM_001351099.1NP_001338028.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:388484
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:475595
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:5931315
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  6. NM_001351100.1NP_001338029.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:388484
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:475597
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:5951317
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  7. NM_001351101.1NP_001338030.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:391487
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:478598
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:5961318
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  8. NM_001351102.1NP_001338031.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Related
    ENSP00000381870.2, ENST00000398896.5
    Conserved Domains (4) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:273369
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:360482
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:4801202
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  9. NM_001351103.1NP_001338032.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:290386
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:377497
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:4951217
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  10. NM_001351104.1NP_001338033.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:290386
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:377499
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:4971219
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  11. NM_001351105.1NP_001338034.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:339435
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:426546
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:5441266
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  12. NM_001351106.1NP_001338035.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:288384
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:375497
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:4951217
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  13. NM_001351107.1NP_001338036.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:374470
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:461583
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:5811303
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  14. NM_001351108.1NP_001338037.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC135506
    Conserved Domains (4) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:275371
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    pfam16602
    Location:362484
    USP19_linker; Linker region of USP19 deubiquitinase
    cl02553
    Location:4821204
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  15. NM_006677.2NP_006668.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 4

    See identical proteins and their annotated locations for NP_006668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC146752, DC323791, DC332671
    Consensus CDS
    CCDS43090.1
    UniProtKB/Swiss-Prot
    O94966
    Related
    ENSP00000381863.2, ENST00000398888.6
    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:288384
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:10551212
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:498684
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:791833
    zf-MYND; MYND finger
    pfam14533
    Location:698757
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:375495
    USP19_linker; Linker region of USP19 deubiquitinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    49108046..49120938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712951.2XP_006713014.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X14

    Conserved Domains (7) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:373469
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11421299
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:585771
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:878920
    zf-MYND; MYND finger
    pfam14533
    Location:785844
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:460582
    USP19_linker; Linker region of USP19 deubiquitinase
  2. XM_006712952.2XP_006713015.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X15

    Conserved Domains (7) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:374470
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11411298
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:584770
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:877919
    zf-MYND; MYND finger
    pfam14533
    Location:784843
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:461581
    USP19_linker; Linker region of USP19 deubiquitinase
  3. XM_017005633.2XP_016861122.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X24

    UniProtKB/Swiss-Prot
    O94966
  4. XM_017005619.2XP_016861108.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X10

  5. XM_017005624.2XP_016861113.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X16

  6. XM_006712948.3XP_006713011.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X11

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:389485
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11561313
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:599785
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:892934
    zf-MYND; MYND finger
    pfam14533
    Location:799858
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:476596
    USP19_linker; Linker region of USP19 deubiquitinase
  7. XM_005264829.3XP_005264886.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X9

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:391487
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11601317
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:603789
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:896938
    zf-MYND; MYND finger
    pfam14533
    Location:803862
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:478600
    USP19_linker; Linker region of USP19 deubiquitinase
  8. XM_017005628.1XP_016861117.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X21

  9. XM_017005627.1XP_016861116.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X20

  10. XM_006712947.2XP_006713010.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X8

    Conserved Domains (7) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:373469
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11421299
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:585771
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:878920
    zf-MYND; MYND finger
    pfam14533
    Location:785844
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:460582
    USP19_linker; Linker region of USP19 deubiquitinase
  11. XM_017005617.1XP_016861106.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X7

  12. XM_005264827.2XP_005264884.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X6

    Conserved Domains (7) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:376472
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11451302
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:588774
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:881923
    zf-MYND; MYND finger
    pfam14533
    Location:788847
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:463585
    USP19_linker; Linker region of USP19 deubiquitinase
  13. XM_006712953.1XP_006713016.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X23

    Conserved Domains (7) summary
    cd06463
    Location:105187
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:374470
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11411298
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:584770
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:877919
    zf-MYND; MYND finger
    pfam14533
    Location:784843
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:461581
    USP19_linker; Linker region of USP19 deubiquitinase
  14. XM_017005625.2XP_016861114.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X18

  15. XM_005264830.3XP_005264887.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X17

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:290386
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:10591216
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:502688
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:795837
    zf-MYND; MYND finger
    pfam14533
    Location:702761
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:377499
    USP19_linker; Linker region of USP19 deubiquitinase
  16. XM_017005616.2XP_016861105.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X5

  17. XM_006712946.3XP_006713009.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X2

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:390486
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11591316
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:602788
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:895937
    zf-MYND; MYND finger
    pfam14533
    Location:802861
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:477599
    USP19_linker; Linker region of USP19 deubiquitinase
  18. XM_017005621.2XP_016861110.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X13

  19. XM_006712949.3XP_006713012.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X12

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:341437
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11101267
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:553739
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:846888
    zf-MYND; MYND finger
    pfam14533
    Location:753812
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:428550
    USP19_linker; Linker region of USP19 deubiquitinase
  20. XM_005264825.3XP_005264882.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X3

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:389485
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11581315
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:601787
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:894936
    zf-MYND; MYND finger
    pfam14533
    Location:801860
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:476598
    USP19_linker; Linker region of USP19 deubiquitinase
  21. XM_005264826.3XP_005264883.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X4

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:391487
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11581315
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:601787
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:894936
    zf-MYND; MYND finger
    pfam14533
    Location:801860
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:478598
    USP19_linker; Linker region of USP19 deubiquitinase
  22. XM_005264823.3XP_005264880.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

    See identical proteins and their annotated locations for XP_005264880.1

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:391487
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11601317
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:603789
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:896938
    zf-MYND; MYND finger
    pfam14533
    Location:803862
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:478600
    USP19_linker; Linker region of USP19 deubiquitinase
  23. XM_017005629.1XP_016861118.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X22

  24. XM_017005626.1XP_016861115.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X19

    UniProtKB/Swiss-Prot
    O94966
    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:288384
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:10551212
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:498684
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:791833
    zf-MYND; MYND finger
    pfam14533
    Location:698757
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:375495
    USP19_linker; Linker region of USP19 deubiquitinase
  25. XM_005264824.2XP_005264881.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

    See identical proteins and their annotated locations for XP_005264881.1

    Conserved Domains (7) summary
    cd06463
    Location:120202
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:391487
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:11601317
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:603789
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:896938
    zf-MYND; MYND finger
    pfam14533
    Location:803862
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:478600
    USP19_linker; Linker region of USP19 deubiquitinase
  26. XM_017005635.1XP_016861124.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X25

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