U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Edem2 ER degradation enhancer, mannosidase alpha-like 2 [ Mus musculus (house mouse) ]

Gene ID: 108687, updated on 25-May-2024

Summary

Official Symbol
Edem2provided by MGI
Official Full Name
ER degradation enhancer, mannosidase alpha-like 2provided by MGI
Primary source
MGI:MGI:1915540
See related
Ensembl:ENSMUSG00000038312 AllianceGenome:MGI:1915540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530090G24Rik
Summary
Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in positive regulation of retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 45.8), ovary adult (RPKM 41.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Edem2 in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155543593..155571395, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155701673..155729475, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene protein C receptor, endothelial Neighboring gene matrix metallopeptidase 24 Neighboring gene predicted gene, 46772

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ER degradation-enhancing alpha-mannosidase-like protein 2
NP_663512.2
XP_030102389.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145537.2NP_663512.2  ER degradation-enhancing alpha-mannosidase-like protein 2 precursor

    See identical proteins and their annotated locations for NP_663512.2

    Status: VALIDATED

    Source sequence(s)
    AK166998, AL929233, BY289191
    Consensus CDS
    CCDS16953.1
    UniProtKB/Swiss-Prot
    Q8BJR2, Q8BJT9, Q8BK85, Q91VV3
    Related
    ENSMUSP00000041202.5, ENSMUST00000040833.5
    Conserved Domains (1) summary
    pfam01532
    Location:42480
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155543593..155571395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246529.2XP_030102389.1  ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1

    Conserved Domains (1) summary
    cl04955
    Location:3204
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

RNA

  1. XR_866205.2 RNA Sequence