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USP20 ubiquitin specific peptidase 20 [ Homo sapiens (human) ]

Gene ID: 10868, updated on 10-May-2020

Summary

Official Symbol
USP20provided by HGNC
Official Full Name
ubiquitin specific peptidase 20provided by HGNC
Primary source
HGNC:HGNC:12619
See related
Ensembl:ENSG00000136878 MIM:615143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VDU2; hVDU2; LSFR3A
Summary
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in lymph node (RPKM 8.9), bone marrow (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See USP20 in Genome Data Viewer
Location:
9q34.11
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (129835417..129881838)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132597696..132644121)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene torsin family 1 member A Neighboring gene chromosome 9 open reading frame 78 Neighboring gene Sharpr-MPRA regulatory region 12063 Neighboring gene microRNA 6855 Neighboring gene formin binding protein 1 Neighboring gene G protein-coupled receptor 107

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin specific peptidase 20 (USP20) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of ubiquitin specific peptidase 20 (USP20) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1003

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IEA
Inferred from Electronic Annotation
more info
 
thiol-dependent ubiquitinyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 20
Names
deubiquitinating enzyme 20
pVHL-interacting deubiquitinating enzyme 2
ubiquitin thioesterase 20
ubiquitin thiolesterase 20
ubiquitin-specific-processing protease 20
NP_001008563.2
NP_001103773.2
NP_006667.3
XP_005251722.1
XP_011516463.1
XP_011516464.1
XP_024303157.1
XP_024303158.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033097.1 RefSeqGene

    Range
    5001..51422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008563.4NP_001008563.2  ubiquitin carboxyl-terminal hydrolase 20

    See identical proteins and their annotated locations for NP_001008563.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has different 5' and 3' non-coding, terminal exons, compared to transcript variant 1. All three transcript variants encode the same protein.
    Source sequence(s)
    AL158207, AY074877, BC039593, BF727180, BM678735
    Consensus CDS
    CCDS43892.1
    UniProtKB/Swiss-Prot
    Q9Y2K6
    Related
    ENSP00000351122.1, ENST00000358355.5
    Conserved Domains (5) summary
    smart00695
    Location:810895
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:144291
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:144682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. NM_001110303.4NP_001103773.2  ubiquitin carboxyl-terminal hydrolase 20

    See identical proteins and their annotated locations for NP_001103773.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a different 3' non-coding, terminal exon, compared to transcript variant 1. All three transcript variants encode the same protein.
    Source sequence(s)
    AL158207
    Consensus CDS
    CCDS43892.1
    UniProtKB/Swiss-Prot
    Q9Y2K6
    Related
    ENSP00000361506.3, ENST00000372429.7
    Conserved Domains (5) summary
    smart00695
    Location:810895
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:144291
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:144682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  3. NM_006676.7NP_006667.3  ubiquitin carboxyl-terminal hydrolase 20

    See identical proteins and their annotated locations for NP_006667.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three transcript variants encode the same protein.
    Source sequence(s)
    AL158207, BC039593, BF727180, BM678735
    Consensus CDS
    CCDS43892.1
    UniProtKB/Swiss-Prot
    Q9Y2K6
    Related
    ENSP00000313811.4, ENST00000315480.9
    Conserved Domains (5) summary
    smart00695
    Location:810895
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:144291
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:144682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    129835417..129881838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251665.3XP_005251722.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

    See identical proteins and their annotated locations for XP_005251722.1

    UniProtKB/Swiss-Prot
    Q9Y2K6
    Conserved Domains (5) summary
    smart00695
    Location:810895
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:144291
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:144682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. XM_024447390.1XP_024303158.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X2

    Conserved Domains (2) summary
    smart00695
    Location:571656
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:204444
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  3. XM_011518161.2XP_011516463.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

    See identical proteins and their annotated locations for XP_011516463.1

    UniProtKB/Swiss-Prot
    Q9Y2K6
    Conserved Domains (5) summary
    smart00695
    Location:810895
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:144291
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:144682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  4. XM_024447389.1XP_024303157.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X2

    Conserved Domains (2) summary
    smart00695
    Location:571656
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:204444
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  5. XM_011518162.2XP_011516464.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

    See identical proteins and their annotated locations for XP_011516464.1

    UniProtKB/Swiss-Prot
    Q9Y2K6
    Conserved Domains (5) summary
    smart00695
    Location:810895
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:144291
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:144682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
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