HCP5 HLA complex P5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HCP5provided by HGNC
Official Full Name: HLA complex P5provided by HGNC
Primary source: HGNC:HGNC:21659
See related: Ensembl:ENSG00000206337 MIM:604676
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P5-1; 6S2650E; D6S2650E
Expression: Broad expression in spleen (RPKM 38.9), lymph node (RPKM 31.9) and 24 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6p21.33

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	6	NC_000006.12 (31463180..31465809)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (31430957..31433586)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HCP5 rs2395029 is a rapid and inexpensive alternative to HLA-B*57:01 genotyping to predict abacavir hypersensitivity reaction in Spain.
Title: HCP5 rs2395029 is a rapid and inexpensive alternative to HLA-B*57:01 genotyping to predict abacavir hypersensitivity reaction in Spain.
Long non-coding RNA HCP5 in cancer.
Title: Long non-coding RNA HCP5 in cancer.
LncRNA HCP5 Regulates Pancreatic Cancer Progression by miR-140-5p/CDK8 Axis.
Title: LncRNA HCP5 Regulates Pancreatic Cancer Progression by miR-140-5p/CDK8 Axis.
LncRNA HCP5 promotes LAML progression via PSMB8-mediated PI3K/AKT pathway activation.
Title: LncRNA HCP5 promotes LAML progression via PSMB8-mediated PI3K/AKT pathway activation.
MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1alpha/CEBPB axis to promote stemness and chemo-resistance of gastric cancer.
Title: MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer.
Long non-coding RNA HCP5 promotes proliferation and metastasis of clear cell renal cell carcinoma via targeting miR-140-5p/IGF1R pathway.
Title: Long non-coding RNA HCP5 promotes proliferation and metastasis of clear cell renal cell carcinoma via targeting miR-140-5p/IGF1R pathway.
An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.
Title: An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.
Down-regulation of HCP5 inhibits cell proliferation, migration, and invasion through regulating EPHA7 by competitively binding miR-101 in osteosarcoma.
Title: Down-regulation of HCP5 inhibits cell proliferation, migration, and invasion through regulating EPHA7 by competitively binding miR-101 in osteosarcoma.
The Effect of Long Non-Coding RNA (lncRNA) HCP5 on Regulating Epithelial-Mesenchymal Transition (EMT)-Related Markers in Gastric Carcinoma Is Partially Reversed by miR-27b-3p.
Title: The Effect of Long Non-Coding RNA (lncRNA) HCP5 on Regulating Epithelial-Mesenchymal Transition (EMT)-Related Markers in Gastric Carcinoma Is Partially Reversed by miR-27b-3p.
LncRNA HCP5 promotes cell proliferation and inhibits apoptosis via miR-27a-3p/IGF-1 axis in human granulosa-like tumor cell line KGN.
Title: LncRNA HCP5 promotes cell proliferation and inhibits apoptosis via miR-27a-3p/IGF-1 axis in human granulosa-like tumor cell line KGN.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. GeneReviews: Not available
A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. GeneReviews: Not available
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. GeneReviews: Not available
Common genetic variation and the control of HIV-1 in humans. GeneReviews: Not available
Genetic variation in the HLA region is associated with susceptibility to herpes zoster. GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. GeneReviews: Not available
Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. GeneReviews: Not available
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). GeneReviews: Not available
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. GeneReviews: Not available
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. GeneReviews: Not available
Novel associations for hypothyroidism include known autoimmune risk loci. GeneReviews: Not available
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. GeneReviews: Not available

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH46617 (e-PCR)
- UniSTS:25471

NoName (e-PCR)
- UniSTS:487045

RH17599 (e-PCR)
- UniSTS:14045

Other Names

HLA class I histocompatibility antigen protein P5
HLA complex P5 (non-protein coding)
HLA complex protein P5
MHC class I region ORF

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.