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Foxp1 forkhead box P1 [ Mus musculus (house mouse) ]

Gene ID: 108655, updated on 24-Dec-2019

Summary

Official Symbol
Foxp1provided by MGI
Official Full Name
forkhead box P1provided by MGI
Primary source
MGI:MGI:1914004
See related
Ensembl:ENSMUSG00000030067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI461938; AW494214; 3110052D19Rik; 4932443N09Rik
Expression
Ubiquitous expression in spleen adult (RPKM 9.3), lung adult (RPKM 7.6) and 28 other tissues See more
Orthologs

Genomic context

See Foxp1 in Genome Data Viewer
Location:
6; 6 D3
Exon count:
39
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (98925342..99522746, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (98880084..99113012, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930595L18 gene Neighboring gene predicted gene, 32308 Neighboring gene predicted gene, 19665 Neighboring gene predicted gene, 38865 Neighboring gene predicted gene, 51278 Neighboring gene predicted gene, 52870 Neighboring gene predicted gene, 32882 Neighboring gene eukaryotic translation initiation factor 4E member 3 Neighboring gene predicted gene, 52869 Neighboring gene G protein-coupled receptor 27

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T follicular helper cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiovascular system development IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiovascular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to ionomycin ISO
Inferred from Sequence Orthology
more info
 
embryo development IGI
Inferred from Genetic Interaction
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-21 secretion IDA
Inferred from Direct Assay
more info
PubMed 
lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
lung secretory cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lung goblet cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of hydrogen peroxide-induced cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
pre-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lung goblet cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
sarcomere organization IGI
Inferred from Genetic Interaction
more info
PubMed 
skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
smooth muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
ventral spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
forkhead box protein P1
Names
forkhead-related transcription factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197321.1NP_001184250.1  forkhead box protein P1 isoform 2

    See identical proteins and their annotated locations for NP_001184250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA451299, AC125137, AI508521, BC064764
    Consensus CDS
    CCDS57442.1
    UniProtKB/Swiss-Prot
    P58462
    UniProtKB/TrEMBL
    A0A0R4J1H9
    Related
    ENSMUSP00000108952.2, ENSMUST00000113326.8
    Conserved Domains (2) summary
    cd00059
    Location:461533
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:298365
    FOXP-CC; FOXP coiled-coil domain
  2. NM_001197322.1NP_001184251.1  forkhead box protein P1 isoform 3

    See identical proteins and their annotated locations for NP_001184251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC125137, AI508521, AK077062
    Consensus CDS
    CCDS57441.1
    UniProtKB/Swiss-Prot
    P58462
    UniProtKB/TrEMBL
    A0A0R4J282
    Related
    ENSMUSP00000135809.1, ENSMUST00000177437.7
    Conserved Domains (2) summary
    cd00059
    Location:364436
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:201268
    FOXP-CC; FOXP coiled-coil domain
  3. NM_001347345.1NP_001334274.1  forkhead box protein P1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. It encodes isoform 4. Isoforms 1 and 4 are identical in length but have distinct peptide sequences.
    Source sequence(s)
    AB594192, AC125137
    Consensus CDS
    CCDS85105.1
    UniProtKB/TrEMBL
    E2S038
    Related
    ENSMUSP00000135181.1, ENSMUST00000176565.7
  4. NM_053202.2NP_444432.1  forkhead box protein P1 isoform 1

    See identical proteins and their annotated locations for NP_444432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Isoforms 1 and 4 are identical in length but have distinct peptide sequences.
    Source sequence(s)
    AC125137, AC132579, AC155839, AC163199
    Consensus CDS
    CCDS39578.1
    UniProtKB/Swiss-Prot
    P58462
    Related
    ENSMUSP00000108948.2, ENSMUST00000113322.8
    Conserved Domains (2) summary
    cd00059
    Location:493565
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:330397
    FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    98925342..99522746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505316.4XP_006505379.1  forkhead box protein P1 isoform X4

    See identical proteins and their annotated locations for XP_006505379.1

    UniProtKB/TrEMBL
    E2S038
    Conserved Domains (2) summary
    cd00059
    Location:493565
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:331398
    FOXP-CC; FOXP coiled-coil domain
  2. XM_030255064.1XP_030110924.1  forkhead box protein P1 isoform X2

    Related
    ENSMUSP00000108954.2, ENSMUST00000113328.8
  3. XM_030255065.1XP_030110925.1  forkhead box protein P1 isoform X3

  4. XM_030255066.1XP_030110926.1  forkhead box protein P1 isoform X3

  5. XM_006505314.4XP_006505377.1  forkhead box protein P1 isoform X2

    UniProtKB/TrEMBL
    D3Z6Q3
    Conserved Domains (2) summary
    cd00059
    Location:494566
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:331398
    FOXP-CC; FOXP coiled-coil domain
  6. XM_006505315.4XP_006505378.1  forkhead box protein P1 isoform X3

    UniProtKB/TrEMBL
    H3BLF2
    Conserved Domains (2) summary
    cd00059
    Location:494566
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  7. XM_017321301.2XP_017176790.1  forkhead box protein P1 isoform X1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  8. XM_030255060.1XP_030110920.1  forkhead box protein P1 isoform X1

  9. XM_017321303.2XP_017176792.1  forkhead box protein P1 isoform X1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  10. XM_006505308.4XP_006505371.1  forkhead box protein P1 isoform X1

    See identical proteins and their annotated locations for XP_006505371.1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  11. XM_017321302.1XP_017176791.1  forkhead box protein P1 isoform X1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  12. XM_017321304.2XP_017176793.1  forkhead box protein P1 isoform X1

    Related
    ENSMUSP00000135041.1, ENSMUST00000176850.7
    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  13. XM_006505310.4XP_006505373.1  forkhead box protein P1 isoform X1

    See identical proteins and their annotated locations for XP_006505373.1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  14. XM_006505311.4XP_006505374.1  forkhead box protein P1 isoform X1

    See identical proteins and their annotated locations for XP_006505374.1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  15. XM_006505312.4XP_006505375.1  forkhead box protein P1 isoform X1

    See identical proteins and their annotated locations for XP_006505375.1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  16. XM_030255059.1XP_030110919.1  forkhead box protein P1 isoform X1

  17. XM_030255063.1XP_030110923.1  forkhead box protein P1 isoform X1

    Related
    ENSMUSP00000108950.2, ENSMUST00000113324.8
  18. XM_030255062.1XP_030110922.1  forkhead box protein P1 isoform X1

  19. XM_030255067.1XP_030110927.1  forkhead box protein P1 isoform X3

    Related
    ENSMUSP00000135764.1, ENSMUST00000177307.7
  20. XM_030255061.1XP_030110921.1  forkhead box protein P1 isoform X1

  21. XM_006505313.4XP_006505376.1  forkhead box protein P1 isoform X1

    See identical proteins and their annotated locations for XP_006505376.1

    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain
  22. XM_030255074.1XP_030110934.1  forkhead box protein P1 isoform X11

  23. XM_030255068.1XP_030110928.1  forkhead box protein P1 isoform X6

  24. XM_017321305.2XP_017176794.1  forkhead box protein P1 isoform X6

    UniProtKB/TrEMBL
    H3BJ24
    Conserved Domains (2) summary
    cd00059
    Location:365437
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:202269
    FOXP-CC; FOXP coiled-coil domain
  25. XM_030255069.1XP_030110929.1  forkhead box protein P1 isoform X7

  26. XM_030255070.1XP_030110930.1  forkhead box protein P1 isoform X8

  27. XM_006505323.4XP_006505386.1  forkhead box protein P1 isoform X7

    See identical proteins and their annotated locations for XP_006505386.1

    UniProtKB/Swiss-Prot
    P58462
    UniProtKB/TrEMBL
    A0A0R4J282
    Conserved Domains (2) summary
    cd00059
    Location:364436
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:201268
    FOXP-CC; FOXP coiled-coil domain
  28. XM_006505320.4XP_006505383.1  forkhead box protein P1 isoform X6

    See identical proteins and their annotated locations for XP_006505383.1

    UniProtKB/TrEMBL
    H3BJ24
    Conserved Domains (2) summary
    cd00059
    Location:365437
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:202269
    FOXP-CC; FOXP coiled-coil domain
  29. XM_006505319.1XP_006505382.1  forkhead box protein P1 isoform X6

    See identical proteins and their annotated locations for XP_006505382.1

    UniProtKB/TrEMBL
    H3BJ24
    Conserved Domains (2) summary
    cd00059
    Location:365437
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:202269
    FOXP-CC; FOXP coiled-coil domain
  30. XM_006505322.1XP_006505385.1  forkhead box protein P1 isoform X7

    See identical proteins and their annotated locations for XP_006505385.1

    UniProtKB/Swiss-Prot
    P58462
    UniProtKB/TrEMBL
    A0A0R4J282
    Conserved Domains (2) summary
    cd00059
    Location:364436
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:201268
    FOXP-CC; FOXP coiled-coil domain
  31. XM_030255072.1XP_030110932.1  forkhead box protein P1 isoform X9

  32. XM_017321306.2XP_017176795.1  forkhead box protein P1 isoform X6

    UniProtKB/TrEMBL
    H3BJ24
    Related
    ENSMUSP00000134817.1, ENSMUST00000177229.7
    Conserved Domains (2) summary
    cd00059
    Location:365437
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:202269
    FOXP-CC; FOXP coiled-coil domain
  33. XM_030255071.1XP_030110931.1  forkhead box protein P1 isoform X8

  34. XM_006505321.1XP_006505384.1  forkhead box protein P1 isoform X6

    See identical proteins and their annotated locations for XP_006505384.1

    UniProtKB/TrEMBL
    H3BJ24
    Conserved Domains (2) summary
    cd00059
    Location:365437
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:202269
    FOXP-CC; FOXP coiled-coil domain
  35. XM_030255073.1XP_030110933.1  forkhead box protein P1 isoform X10

  36. XM_006505318.4XP_006505381.1  forkhead box protein P1 isoform X5

    Related
    ENSMUSP00000135098.1, ENSMUST00000177230.7
    Conserved Domains (2) summary
    cd00059
    Location:495567
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:332399
    FOXP-CC; FOXP coiled-coil domain

RNA

  1. XR_003956146.1 RNA Sequence

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