Foxp1 forkhead box P1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxp1provided by MGI
Official Full Name: forkhead box P1provided by MGI
Primary source: MGI:MGI:1914004
See related: Ensembl:ENSMUSG00000030067 AllianceGenome:MGI:1914004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3110052D19Rik; 4932443N09Rik
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in T follicular helper cell differentiation; motor neuron axon guidance; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; congenital heart disease; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 9.3), lung adult (RPKM 7.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 D3

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (98902303..99510587, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (98925342..99522746, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.
Title: Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.
Endothelial Foxp1 Regulates Neointimal Hyperplasia Via Matrix Metalloproteinase-9/Cyclin Dependent Kinase Inhibitor 1B Signal Pathway.
Title: Endothelial Foxp1 Regulates Neointimal Hyperplasia Via Matrix Metalloproteinase-9/Cyclin Dependent Kinase Inhibitor 1B Signal Pathway.
Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages.
Title: Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages.
Disrupted Mitochondrial Network Drives Deficits of Learning and Memory in a Mouse Model of FOXP1 Haploinsufficiency.
Title: Disrupted Mitochondrial Network Drives Deficits of Learning and Memory in a Mouse Model of FOXP1 Haploinsufficiency.
FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents.
Title: FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents.
A novel epigenetic regulation of circFoxp1 on Foxp1 in colon cancer cells.
Title: A novel epigenetic regulation of circFoxp1 on Foxp1 in colon cancer cells.
Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development.
Title: Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development.
Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.
Title: Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.
An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons.
Title: An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons.
This study revealed that FOXP1-induced CLRN1-AS1 regulated cellular functions in pituitary prolactinoma by sponging miR-217 to release the DKK1/Wnt/beta-catenin signaling pathway.
Title: FOXP1-induced lncRNA CLRN1-AS1 acts as a tumor suppressor in pituitary prolactinoma by repressing the autophagy via inactivating Wnt/β-catenin signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (10) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI461938 (e-PCR)
- UniSTS:159547

D6Mit103 (e-PCR), detects polymorphism
- UniSTS:130647

WI-17713 (e-PCR)
- UniSTS:47790

Foxp1 (e-PCR), detects polymorphism
- UniSTS:498377

Foxp1 (e-PCR), detects polymorphism
- UniSTS:498378

AW494214 (e-PCR)
- UniSTS:179425

Homology

Homologs of the Foxp1 gene: The Foxp1 gene is conserved in Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 478 organisms have orthologs with human gene Foxp1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein self-association	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in T follicular helper cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ionomycin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin V(D)J recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of innate vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung secretory cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lung goblet cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hydrogen peroxide-induced cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-21 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pre-B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lung goblet cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within smooth muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein P1

Names: forkhead-related transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197321.1 → NP_001184250.1 forkhead box protein P1 isoform 2

See identical proteins and their annotated locations for NP_001184250.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AA451299, AC125137, AI508521, BC064764

Consensus CDS

CCDS57442.1

UniProtKB/Swiss-Prot

P58462

UniProtKB/TrEMBL

A0A0R4J1H9

Related

ENSMUSP00000108952.3, ENSMUST00000113326.9

Conserved Domains (2) summary

cd00059
Location:461 → 533

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:298 → 365

FOXP-CC; FOXP coiled-coil domain
NM_001197322.1 → NP_001184251.1 forkhead box protein P1 isoform 3

See identical proteins and their annotated locations for NP_001184251.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC125137, AI508521, AK077062

Consensus CDS

CCDS57441.1

UniProtKB/Swiss-Prot

P58462

UniProtKB/TrEMBL

A0A0R4J282

Related

ENSMUSP00000135809.2, ENSMUST00000177437.8

Conserved Domains (3) summary

COG5025
Location:336 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:364 → 436

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:201 → 268

FOXP-CC; FOXP coiled-coil domain
NM_001347345.1 → NP_001334274.1 forkhead box protein P1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. It encodes isoform 4. Isoforms 1 and 4 are identical in length but have distinct peptide sequences.

Source sequence(s)

AB594192, AC125137

Consensus CDS

CCDS85105.1

UniProtKB/TrEMBL

E2S038

Related

ENSMUSP00000135181.2, ENSMUST00000176565.8

Conserved Domains (3) summary

COG5025
Location:466 → 679

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:493 → 565

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:331 → 398

FOXP-CC; FOXP coiled-coil domain
NM_053202.2 → NP_444432.1 forkhead box protein P1 isoform 1

See identical proteins and their annotated locations for NP_444432.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Isoforms 1 and 4 are identical in length but have distinct peptide sequences.

Source sequence(s)

AC125137, AC132579, AC155839, AC163199

Consensus CDS

CCDS39578.1

UniProtKB/Swiss-Prot

P58462, Q8CCD9

Related

ENSMUSP00000108948.3, ENSMUST00000113322.9

Conserved Domains (3) summary

COG5025
Location:465 → 679

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:330 → 397

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:492 → 573

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

98902303..99510587 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165732.1 → XP_036021625.1 forkhead box protein P1 isoform X3

UniProtKB/TrEMBL

H3BLF2

Conserved Domains (3) summary

COG5025
Location:467 → 680

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:493 → 574

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_036165728.1 → XP_036021621.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505316.5 → XP_006505379.1 forkhead box protein P1 isoform X4

See identical proteins and their annotated locations for XP_006505379.1

UniProtKB/TrEMBL

E2S038

Conserved Domains (3) summary

COG5025
Location:466 → 679

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:493 → 565

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:331 → 398

FOXP-CC; FOXP coiled-coil domain
XM_030255064.2 → XP_030110924.1 forkhead box protein P1 isoform X2

UniProtKB/TrEMBL

D3Z6Q3

Related

ENSMUSP00000108954.3, ENSMUST00000113328.9

Conserved Domains (3) summary

COG5025
Location:466 → 680

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:494 → 566

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:331 → 398

FOXP-CC; FOXP coiled-coil domain
XM_030255065.2 → XP_030110925.1 forkhead box protein P1 isoform X3

UniProtKB/TrEMBL

H3BLF2

Conserved Domains (3) summary

COG5025
Location:467 → 680

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:493 → 574

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_030255066.2 → XP_030110926.1 forkhead box protein P1 isoform X3

UniProtKB/TrEMBL

H3BLF2

Conserved Domains (3) summary

COG5025
Location:467 → 680

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:493 → 574

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505314.5 → XP_006505377.1 forkhead box protein P1 isoform X2

UniProtKB/TrEMBL

D3Z6Q3

Conserved Domains (3) summary

COG5025
Location:466 → 680

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:494 → 566

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:331 → 398

FOXP-CC; FOXP coiled-coil domain
XM_006505315.5 → XP_006505378.1 forkhead box protein P1 isoform X3

UniProtKB/TrEMBL

H3BLF2

Conserved Domains (3) summary

COG5025
Location:467 → 680

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:493 → 574

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_017321301.3 → XP_017176790.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_017321303.3 → XP_017176792.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505308.5 → XP_006505371.1 forkhead box protein P1 isoform X1

See identical proteins and their annotated locations for XP_006505371.1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_036165729.1 → XP_036021622.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_036165731.1 → XP_036021624.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_036165730.1 → XP_036021623.1 forkhead box protein P1 isoform X1

Related

ENSMUSP00000135041.2, ENSMUST00000176850.8

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_017321302.1 → XP_017176791.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_017321304.3 → XP_017176793.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505310.5 → XP_006505373.1 forkhead box protein P1 isoform X1

See identical proteins and their annotated locations for XP_006505373.1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505311.5 → XP_006505374.1 forkhead box protein P1 isoform X1

See identical proteins and their annotated locations for XP_006505374.1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505312.4 → XP_006505375.1 forkhead box protein P1 isoform X1

See identical proteins and their annotated locations for XP_006505375.1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_030255063.2 → XP_030110923.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_030255062.2 → XP_030110922.1 forkhead box protein P1 isoform X1

Related

ENSMUSP00000108950.3, ENSMUST00000113324.9

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_030255061.2 → XP_030110921.1 forkhead box protein P1 isoform X1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_030255067.2 → XP_030110927.1 forkhead box protein P1 isoform X3

UniProtKB/TrEMBL

H3BLF2

Related

ENSMUSP00000135764.2, ENSMUST00000177307.8

Conserved Domains (3) summary

COG5025
Location:467 → 680

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:493 → 574

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505313.4 → XP_006505376.1 forkhead box protein P1 isoform X1

See identical proteins and their annotated locations for XP_006505376.1

Conserved Domains (3) summary

COG5025
Location:467 → 681

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:494 → 575

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_030255074.1 → XP_030110934.1 forkhead box protein P1 isoform X8

Conserved Domains (2) summary

cd00059
Location:495 → 567

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:332 → 399

FOXP-CC; FOXP coiled-coil domain
XM_030255068.2 → XP_030110928.1 forkhead box protein P1 isoform X5

UniProtKB/TrEMBL

A0A8C6N5H4, H3BJ24

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:365 → 437

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain
XM_030255069.2 → XP_030110929.1 forkhead box protein P1 isoform X6

UniProtKB/TrEMBL

A0A0R4J282

Conserved Domains (3) summary

COG5025
Location:336 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:364 → 436

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:201 → 268

FOXP-CC; FOXP coiled-coil domain
XM_030255070.2 → XP_030110930.1 forkhead box protein P1 isoform X7

Conserved Domains (3) summary

COG5025
Location:337 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:363 → 444

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_017321305.3 → XP_017176794.1 forkhead box protein P1 isoform X5

UniProtKB/TrEMBL

A0A8C6N5H4, H3BJ24

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:365 → 437

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain
XM_006505323.4 → XP_006505386.1 forkhead box protein P1 isoform X6

See identical proteins and their annotated locations for XP_006505386.1

UniProtKB/Swiss-Prot

P58462

UniProtKB/TrEMBL

A0A0R4J282

Conserved Domains (3) summary

COG5025
Location:336 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:364 → 436

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:201 → 268

FOXP-CC; FOXP coiled-coil domain
XM_006505320.4 → XP_006505383.1 forkhead box protein P1 isoform X5

See identical proteins and their annotated locations for XP_006505383.1

UniProtKB/TrEMBL

A0A8C6N5H4, H3BJ24

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:365 → 437

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain
XM_036165733.1 → XP_036021626.1 forkhead box protein P1 isoform X7

Conserved Domains (3) summary

COG5025
Location:337 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:363 → 444

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505319.1 → XP_006505382.1 forkhead box protein P1 isoform X5

See identical proteins and their annotated locations for XP_006505382.1

UniProtKB/TrEMBL

A0A8C6N5H4, H3BJ24

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:365 → 437

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain
XM_006505322.1 → XP_006505385.1 forkhead box protein P1 isoform X6

See identical proteins and their annotated locations for XP_006505385.1

UniProtKB/Swiss-Prot

P58462

UniProtKB/TrEMBL

A0A0R4J282

Conserved Domains (3) summary

COG5025
Location:336 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:364 → 436

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:201 → 268

FOXP-CC; FOXP coiled-coil domain
XM_017321306.3 → XP_017176795.1 forkhead box protein P1 isoform X5

UniProtKB/TrEMBL

A0A8C6N5H4, H3BJ24

Related

ENSMUSP00000134817.2, ENSMUST00000177229.8

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:365 → 437

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain
XM_030255071.2 → XP_030110931.1 forkhead box protein P1 isoform X7

Conserved Domains (3) summary

COG5025
Location:337 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:363 → 444

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006505321.1 → XP_006505384.1 forkhead box protein P1 isoform X5

See identical proteins and their annotated locations for XP_006505384.1

UniProtKB/TrEMBL

A0A8C6N5H4, H3BJ24

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd00059
Location:365 → 437

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain