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SLC22A7 solute carrier family 22 member 7 [ Homo sapiens (human) ]

Gene ID: 10864, updated on 21-Dec-2019

Summary

Official Symbol
SLC22A7provided by HGNC
Official Full Name
solute carrier family 22 member 7provided by HGNC
Primary source
HGNC:HGNC:10971
See related
Ensembl:ENSG00000137204 MIM:604995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLT; OAT2; hOAT11
Summary
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 51.8) and kidney (RPKM 19.9) See more
Orthologs

Genomic context

See SLC22A7 in Genome Data Viewer
Location:
6p21.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43295710..43305538)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43265737..43273276)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tau tubulin kinase 1 Neighboring gene uncharacterized LOC105375064 Neighboring gene Sharpr-MPRA regulatory region 10500 Neighboring gene cysteine rich protein 3 Neighboring gene ribosomal protein L12 pseudogene 47 Neighboring gene ribosomal protein L34 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC24091, MGC45202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium-independent organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
organic anion transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 22 member 7
Names
hOAT2
liver-specific transporter
novel liver transporter
organic anion transporter 11
organic anion transporter 2
solute carrier family 22 (organic anion transporter), member 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006672.3NP_006663.2  solute carrier family 22 member 7 isoform a

    See identical proteins and their annotated locations for NP_006663.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AA705161, AF210455, BC033805, DA640137
    Consensus CDS
    CCDS4892.1
    UniProtKB/Swiss-Prot
    Q9Y694
    Related
    ENSP00000361670.3, ENST00000372589.7
    Conserved Domains (2) summary
    cd06174
    Location:126499
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11521
    2A0119; cation transport protein
  2. NM_153320.2NP_696961.2  solute carrier family 22 member 7 isoform b

    See identical proteins and their annotated locations for NP_696961.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate segment in the 5' coding region compared to variant 1. The encoded isoform (b) is longer compared to isoform a.
    Source sequence(s)
    AA705161, BC033805, DA640137
    Consensus CDS
    CCDS4893.2
    UniProtKB/Swiss-Prot
    Q9Y694
    Related
    ENSP00000361666.5, ENST00000372585.9
    Conserved Domains (1) summary
    TIGR00898
    Location:11523
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43295710..43305538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514263.2XP_011512565.1  solute carrier family 22 member 7 isoform X9

    Conserved Domains (1) summary
    cd06174
    Location:1305
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. XM_011514261.2XP_011512563.1  solute carrier family 22 member 7 isoform X7

    Conserved Domains (1) summary
    cd06174
    Location:16373
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_017010199.2XP_016865688.1  solute carrier family 22 member 7 isoform X5

  4. XM_011514256.3XP_011512558.1  solute carrier family 22 member 7 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:206563
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11585
    2A0119; cation transport protein
  5. XM_017010198.2XP_016865687.1  solute carrier family 22 member 7 isoform X3

  6. XM_011514257.3XP_011512559.1  solute carrier family 22 member 7 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:206560
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11582
    2A0119; cation transport protein
  7. XM_024446313.1XP_024302081.1  solute carrier family 22 member 7 isoform X4

    Conserved Domains (1) summary
    cl26863
    Location:11520
    Sugar_tr; Sugar (and other) transporter
  8. XM_024446314.1XP_024302082.1  solute carrier family 22 member 7 isoform X6

    Conserved Domains (1) summary
    cl26863
    Location:11463
    Sugar_tr; Sugar (and other) transporter
  9. XM_011514262.3XP_011512564.1  solute carrier family 22 member 7 isoform X8

    Conserved Domains (2) summary
    cd06174
    Location:206341
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11356
    2A0119; cation transport protein
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