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ADAM28 ADAM metallopeptidase domain 28 [ Homo sapiens (human) ]

Gene ID: 10863, updated on 1-Aug-2020

Summary

Official Symbol
ADAM28provided by HGNC
Official Full Name
ADAM metallopeptidase domain 28provided by HGNC
Primary source
HGNC:HGNC:206
See related
Ensembl:ENSG00000042980 MIM:606188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDCL; MDC-L; eMDCII; ADAM 28; eMDC II
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Biased expression in stomach (RPKM 21.4), gall bladder (RPKM 11.1) and 12 other tissues See more
Orthologs

Genomic context

See ADAM28 in Genome Data Viewer
Location:
8p21.2
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (24294040..24359014)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (24151553..24212726)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986931 Neighboring gene uncharacterized LOC105379328 Neighboring gene RNA, U1 small nuclear 148, pseudogene Neighboring gene uncharacterized LOC101929294 Neighboring gene ADAM like decysin 1 Neighboring gene uncharacterized LOC101929315 Neighboring gene ADAM metallopeptidase domain 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 28
Names
epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
epididymis secretory sperm binding protein
metalloproteinase-like, disintegrin-like, and cysteine-rich protein-L
NP_001291280.1
NP_055080.2
NP_068547.2
XP_005273437.1
XP_005273439.1
XP_006716336.1
XP_006716337.1
XP_011542669.1
XP_011542670.1
XP_011542671.1
XP_011542672.1
XP_011542673.1
XP_016868463.1
XP_016868464.1
XP_016868465.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029394.2 RefSeqGene

    Range
    5003..69948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001304351.2NP_001291280.1  disintegrin and metalloproteinase domain-containing protein 28 isoform 4 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
    Source sequence(s)
    AC120193, AJ242015, AK225921, BC144140, BE833805, BM992381, DA933009
    UniProtKB/Swiss-Prot
    Q9UKQ2
    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_014265.6NP_055080.2  disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_055080.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as MDC-Lm) encodes the longest isoform (1).
    Source sequence(s)
    AC120193, AJ242015, BE833805, BM992381, DA933009
    Consensus CDS
    CCDS34865.1
    UniProtKB/Swiss-Prot
    Q9UKQ2
    Related
    ENSP00000265769.4, ENST00000265769.9
    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  3. NM_021777.4NP_068547.2  disintegrin and metalloproteinase domain-containing protein 28 isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_068547.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as MDC-Ls) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC120193, AF137335, AJ242015, AK225921, DA933009
    Consensus CDS
    CCDS47830.1
    UniProtKB/Swiss-Prot
    Q9UKQ2
    Related
    ENSP00000393699.2, ENST00000437154.6
    Conserved Domains (4) summary
    smart00050
    Location:416490
    DISIN; Homologues of snake disintegrins
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:29156
    Pep_M12B_propep; Reprolysin family propeptide
    cl15456
    Location:493531
    ADAM_CR; ADAM cysteine-rich

RNA

  1. NR_130709.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several alternate exons and its 3' terminal exon extends past a splice site that is used in variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC120193, AF137335, AK293382, AK303437, DA933009
  2. NR_130710.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks one alternate internal exon, contains one alternate internal exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC120193, AJ242015, AK293382, AK303437, BC144140, BE833805, BM992381

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    24294040..24359014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273380.4XP_005273437.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X4

    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  2. XM_017012974.2XP_016868463.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X3

  3. XM_011544368.3XP_011542670.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X6

    See identical proteins and their annotated locations for XP_011542670.1

    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  4. XM_017012975.2XP_016868464.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X5

  5. XM_006716273.3XP_006716336.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X1

    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  6. XM_011544367.3XP_011542669.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X2

    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  7. XM_006716274.1XP_006716337.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X6

    See identical proteins and their annotated locations for XP_006716337.1

    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  8. XM_011544369.2XP_011542671.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X8

    Conserved Domains (5) summary
    smart00608
    Location:493620
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  9. XM_005273382.1XP_005273439.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X9

    Conserved Domains (5) summary
    smart00608
    Location:493610
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:204397
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416488
    Disintegrin; Disintegrin
    pfam01421
    Location:204399
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40155
    Pep_M12B_propep; Reprolysin family propeptide
  10. XM_017012976.1XP_016868465.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X7

  11. XM_011544370.2XP_011542672.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X10

    Conserved Domains (3) summary
    smart00608
    Location:260387
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:1164
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:183255
    Disintegrin; Disintegrin
  12. XM_011544371.3XP_011542673.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X11

    Conserved Domains (3) summary
    smart00608
    Location:240367
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:1144
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:163235
    Disintegrin; Disintegrin

RNA

  1. XR_247120.3 RNA Sequence

  2. XR_949375.3 RNA Sequence

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