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PGRMC1 progesterone receptor membrane component 1 [ Homo sapiens (human) ]

Gene ID: 10857, updated on 7-Jun-2020

Summary

Official Symbol
PGRMC1provided by HGNC
Official Full Name
progesterone receptor membrane component 1provided by HGNC
Primary source
HGNC:HGNC:16090
See related
Ensembl:ENSG00000101856 MIM:300435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IZA; MPR; Dap1; HPR6.6
Summary
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues See more
Orthologs

Genomic context

See PGRMC1 in Genome Data Viewer
Location:
Xq24
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (119236245..119244466)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118370211..118378429)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 28 Neighboring gene NUDT19 pseudogene 6 Neighboring gene A-kinase anchor protein 17B-like Neighboring gene A-kinase anchoring protein 17B, pseudogene Neighboring gene uncharacterized LOC101928336

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
heme biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
smooth endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
membrane-associated progesterone receptor component 1
Names
progesterone binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016756.1 RefSeqGene

    Range
    5038..13219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282621.1NP_001269550.1  membrane-associated progesterone receptor component 1 isoform 2

    See identical proteins and their annotated locations for NP_001269550.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC004835, AK293618, HY166171, R49086
    Consensus CDS
    CCDS65313.1
    UniProtKB/Swiss-Prot
    O00264
    Related
    ENSP00000442821.1, ENST00000535419.2
    Conserved Domains (1) summary
    cl02041
    Location:74107
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  2. NM_006667.5NP_006658.1  membrane-associated progesterone receptor component 1 isoform 1

    See identical proteins and their annotated locations for NP_006658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004835, Y12711
    Consensus CDS
    CCDS14576.1
    UniProtKB/Swiss-Prot
    O00264
    UniProtKB/TrEMBL
    Q6IB11
    Related
    ENSP00000217971.7, ENST00000217971.8
    Conserved Domains (1) summary
    pfam00173
    Location:74137
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    119236245..119244466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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